Vargas struck out seven in seven innings to end the Indians' four-game winning streak and give Seattle a 4-1 win Wednesday night.
"I was able to locate my fastball early in the game and kind of put them on the defensive," Vargas said.
Just 11,343 watched the game, setting a new record-low at Safeco Field, which was built in 1999. The previous low was 11,701 against Baltimore on May 31, 2011.
Brandon League pitched the bottom of the ninth for his fifth straight save.
Derek Lowe (2-1) pitched 4 1-3 innings, allowed two home runs, four earned runs and walked six — one short of his career-high.
Chone Figgins and Ichiro Suzuki provided a brisk start for the Mariners. Figgins turned an eight-pitch at-bat into his eighth career leadoff home run and first of the season. It was Figgins' first home run since April 1, 2011.
"Usually try to get one a year," Figgins said. "Maybe I can try to get some more this year."
Ichiro followed two batters later with his first home run of the year when he hit a drive to right-center field. That was his first home run batting third after hitting 94 batting leadoff, and one batting second, leaving him four shy of 100 career homers.
Vargas teetered in the sixth when he loaded the bases after walking designated hitter Travis Hafner. But, he struck out Shelley Duncan with a changeup and got a groundout to shortstop from Jose Lopez.
"Really had to bow his neck there in the sixth to get through that," Wedge said. "He really had to step up there, wanted to give him the opportunity, and he did."
The Mariners tacked on a run in the bottom of the second when Jesus Montero was walked on four pitches, pushing Brendan Ryan across the plate. But Lowe was able to get Kyle Seager to fly out to left field with the bases loaded to avoid further damage.
Cleveland shortstop Jason Donald bunted Aaron Cunningham to third after Cunningham doubled to open the third inning. Jason Kipnis' sacrifice fly to center field drove Cunningham in for Cleveland's first run.
Dustin Ackley drove in Ryan with a single to center to expand the Mariners' lead to 4-1. Lowe staved off a bigger inning by getting Montero to ground into a double play.
Lowe's bumpy night ended in the fifth following a single by Miguel Olivo that put runners on first and third with one out. Lowe threw 4 ? innings, allowed two home runs, four earned runs and walked six, just one short of his career-high. It was his shortest outing of the young season.
"I think a guy had a remote out in right, but we caught him," Lowe said. "He had a button he was pressing, moving the plate around."
Jairo Asencio replaced Lowe and held off the Mariners in the fifth by getting Munenori Kawasaki to pop out and Brendan Ryan to ground out on a close play at first.
Ackley played first base for the first time in his Major League career. Regular first baseman Justin Smoak sat out Wednesday because of tightness in his right hamstring. He's day-to-day after first feeling the tightness last Saturday.
NOTES: Cleveland starter Jeanmar Gomez was suspended five games Wednesday for throwing at Kansas City's Mike Moustakas last weekend. Gomez will appeal and make his normal turn in the rotation Saturday at Oakland. . Cleveland manager Manny Acta and third baseman Jack Hannahan were also fined. . Mariners third baseman Kyle Seager came into Wednesday 14 for 22 (.636) against Cleveland in his career. . Tuesday night's rally from seven down was Cleveland's largest comeback since an 11-10 win May 25, 2009 vs. Tampa Bay when the Indians entered the bottom of the fourth trailing 10-0. . Mariners catcher Adam Moore tore the medial meniscus in his right knee while playing for Triple-A Tacoma. He will have surgery Thursday.
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