Fowles got her eighth straight double-double, matching her own single-season league record set last year. Tamera Young scored 12 points and Ruth Riley added 10 for Chicago (7-1), which never trailed.
Tina Thompson scored 13 points and Ann Wauters had 12 as Seattle (1-7) dropped its sixth straight on the road and fourth in a row overall.
The Sky led by nine at halftime and stretched it to 11 early in the third quarter before the Storm pulled within four heading to the fourth. However, Chicago outscored Seattle 16-3 over the first 7:12 of the final period to take a 70-53 lead with 2:48 to go.
The Sky outrebounded the Storm 44-21 and shot 44 percent (32 for 72) from the field. Seattle was just 38 percent (20 for 53).
Thompson picked up Seattle's first offensive rebound midway through the third quarter as the Storm trimmed a double-digit deficit to 54-50 on Ewelina Kobryn's layup in the final minute of the period.
Fowles had eight points and three rebounds and Prince scored six points as the Sky took a 20-13 lead after one quarter.
Chicago opened its biggest lead of the half at 40-29 just before the break on Sonja Petrovic's jumper with a minute to go. Prince had six more points in the period.
Wauters had 10 first-half points for the Storm, who were outrebounded 23-11 over the first 20 minutes.
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