Lt. Gregg Hastings says a 2007 Kia Rio was traveling westbound in the eastbound lanes late Friday when it collided with a pickup driven by 53-year-old James Schneider of White Salmon.
The 36-year-old woman driving the Kia died at the scene. Her name has not been released.
Schneider was taken to a Portland hospital with serious injuries.
Hastings says at least one driver complained about a wrong-way vehicle just before crash.
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