Mills was in his third season as manager of the Astros, who have the worst record in the major leagues. The team announced the moves in an email almost two hours after it lost to the Arizona Diamondbacks 12-4 on Saturday night to fall to 39-82.
Houston also fired hitting coach Mike Barnett and first base coach Bobby Meacham. The Astros say first-year general manager Jeff Luhnow will name an interim manager and other staff members in a news conference Sunday morning.
Mills became the first big league manager to be fired this season. He was 76-86 in his first season with Houston and a franchise-worst 56-106 last year.
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