Pistorius wins Paralympic gold in 400 relay
The double amputee, known as "Blade Runner," anchored the team home in a time of 41.78 seconds. South Africa set the previous record at 42.50 in February.
It is Pistorius' fifth Paralympic gold across three games. He won the 200 in Athens in 2004 and the 100, 200 and 400 in Beijing in 2008.
He has already won a silver in the 200 in London after being edged by Alan Oliveira of Brazil in Sunday's final.
Pistorius will go for gold in the 100 on Thursday after qualifying on Wednesday night, and will defend his 400 title Saturday.
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