The Aggies (10-2, 6-2 SEC) scored touchdowns on their first six drives to build a 42-7 halftime lead and coast to their first 10-win season since 1998.
About the only drama in this one came when Manziel, the Heisman Trophy hopeful, was shaken up on a tackle at the end of a run in the first quarter.
But Johnny Football missed just four plays before returning with a brace on his left knee. And it didn't seem to slow him down one bit.
The Aggies were up 21-0 when he returned, and he threw touchdown passes on three straight possessions to end the first half.
Missouri (5-7, 2-6) won't make a bowl game in its first SEC season.
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