The 10th-seeded Cyclones (23-11) will play No. 2 seed Ohio State on Sunday. The Buckeyes advanced with a 95-70 thrashing of Iona.
Iowa State led the nation in 3-pointers this season, but the Cyclones were just as effective from short range in ousting the Fighting Irish (25-10), who played their final game as a member of the Big East and will join the Atlantic Coast Conference next season.
Melvin Ejim added 17 points for Iowa State, which shot better than 70 percent for much of the second half.
Tom Knight scored 14 to lead the Fighting Irish.
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