Mark Lyons matched his career high with 27 points to lead the sixth-seeded Wildcats (27-7). Arizona sprinted to a 30-9 lead, as the Crimson (20-10) missed 20 of its first 22 shots.
Lyons led Arizona to the program's 15th appearance in the Sweet 16. The Wildcats will play Iowa State or Ohio State next week in Los Angeles.
Harvard, meanwhile, goes home with its first NCAA win in tow. The 14th-seeded Crimson beat third-seeded New Mexico on Thursday but couldn't recreate the magic.
Kenyatta Smith led Harvard with 10 points. Freshman Siyani Chambers lost part of his front tooth after Arizona's Kevin Parrom elbowed him in the face.
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