The CBS show, daytime's top-rated soap since December 1988, hit the big 4-0 on Tuesday.
No one from its debut on March 26, 1973 -- when it was just 30 minutes long -- remains with the show, but Jeanne Cooper arrived six months later and is the longest-tenured cast member in her role as grand dame Katherine Chancellor.
"God knows it's claimed a big part of my life," the 84-year-old actress said, citing good writing and likable characters as reasons for the show's continued success in an era of dwindling daytime audiences, network budget-cutting and the cancellation of other soaps.
"Its foundation was set so well and you had core characters that you could grow and become involved with," Cooper said. "As you got older, they got a year older. Whether you were wealthy or whatever your status is, our show hit the human being."
An influx of new, younger cast members has arrived since last year to stir the pot in Genoa City, Wis.
"It's an important time to start looking toward the future and the next generation," said Angelica McDaniel, senior vice president of daytime for CBS. "We're not going to rest on our laurels because we're No. 1."
Among the newbies is Lamon Archey, who, as Mason Wilder, gets to mix it up with Eric Braeden, now in his 33rd year playing ruthless tycoon Victor Newman.
Angell Conwell plays attorney Leslie Michaelson, who keeps it strictly business with Braeden's character while getting frisky with businessman Neil Winters played by Kristoff St. John.
Speaking of alpha-male Braeden, he and Nikki Newman, played by Melody Thomas Scott, recently married for the fourth time, giving the couple 27 weddings between them.
Behind the camera, Jill Farren Phelps took over as executive producer last fall after 11 years of overseeing ABC's "General Hospital," which marks its 50th anniversary next month.
"The greatest challenge when I first came in was to respect the history and legacy of this show. We don't make a decision without careful consideration," she said.
"The heart of this show are the characters. The soul has always been the storytelling."
In January, Phelps brought in Steve Burton to play war veteran Dylan McAvoy three months after his long run on "General Hospital" had ended in part because he wanted to spend more time with his family in Nashville, Tenn. He commutes to Los Angeles for tapings.
Head writer Josh Griffin is loath to give away upcoming story lines, but he promises that "we're going to get hotter and sexier and more romantic and suspenseful as the months go by."
Just the thing to while away an afternoon.
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