Devotees undergo the hardships in the belief that such extreme sacrifices are a way to atone for their sins, attain miracle cures for illnesses or give thanks to God.
Alex Laranang, a 58-year-old vendor who was the first to be nailed to a cross Friday, said he was doing it "for good luck and for my family to be healthy."
It was the 27th crucifixion for sign painter Ruben Enaje, 52, one of the most popular penitents from San Pedro Cutud village. He began his yearly rite after surviving a fall from a building.
Enaje screamed in pain as men dressed as Roman soldiers hammered stainless steel nails into his palms and feet. A wireless microphone carried his voice to loudspeakers for everyone watching to hear.
His cross was raised and he was hanged there for several minutes under the searing afternoon sun before the nails were pulled out and he was taken on a stretcher to a first aid station.
"It's intriguing and fascinating what makes people do something like this, how you can believe so much that you make yourself suffer to that extent," said Dita Tittesass, a tourist from Denmark.
Remigio de la Cruz, the chief of San Pedro Cutud village, explained that the practice began in his village in the 1950s.
Archbishop Jose Palma, president of the Catholic Bishops Conference of the Philippines, told the church-run Radio Veritas that the practice is "not the desire of Jesus Christ."
"We are aware that this has been practiced long before ... but we still hope that this will not be done any more," he said. "We should all concentrate on prayers."
More Nation & World Headlines
NASA opens up patents to inventors, for free The kids are all right with breaking up in person New push could revive Ex-Im Bank Ben Carson leads Clinton in key states Putin spends birthday playing hockey with NHL stars Russia fires missiles as Syrian troops launch ground push Scientists win Nobel chemistry award for work on DNA repair Nuclear smugglers sought terrorist buyers
Our new comment system is not supported in IE 7. Please upgrade your browser here.