Iman Shumpert added 15 points, including a sensational follow dunk in the first half, and Raymond Felton scored 14 as the Knicks turned a close game into a blowout over the final 15 minutes.
Paul George scored 20 points for the Pacers, who had a two-point lead and momentum when coach Frank Vogel called timeout with a little more than 3 minutes left in the third quarter.
By the time the Pacers made their next basket, the Knicks had opened a 26-point advantage.
Game 3 is Saturday at Indianapolis.
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