This time, Lowe -- who's previously played the White House deputy communications director on NBC's "The West Wing" and a senator on ABC's soap "Brothers & Sisters" -- will play President John F. Kennedy in NatGeo's "Killing Kennedy," based on Bill O'Reilly and Martin Dugard's book of the same name.
The story begins in 1959 and follows Kennedy and assassin Lee Harvey Oswald until their paths cross in Dallas in 1963.
"Killing Kennedy" is set to unveil later this year, timed to the 50th anniversary of Kennedy's assassination in November.
It's NatGeo's second go-round with Lowe this year. In April, he narrated the six-part miniseries "The '80s: The Decade that Made Us."
Hey! Isn't that the decade that Lowe campaigned for presidential candidate Michael Dukakis and picked up two chicks in a nightclub at the Democratic National Convention in Atlanta, and changed the course of his career for a while?
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