It was just the second win of Truex's career, first since Dover in 2007. It put Michael Waltrip Racing in Victory Lane for the second year in a row after Clint Bowyer won here last season.
Truex worked his way to the front and used strategy to stay with the leaders. He then pulled away after the final restart and built a healthy lead of more than six seconds over Juan Pablo Montoya.
Jeff Gordon finished second a week after he was wrecked six laps into the race at Michigan.
Carl Edwards was third, followed by Kurt Busch, who climbed back from a pair of speeding penalties.
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