Eighth-seeded Del Potro, the 2009 U.S. Open champion, overcame a 3-0 deficit in the second-set tiebreaker to win, then took the third set in 31 minutes.
Del Potro, who didn't play the French Open because of a respiratory illness, is the only man left in the Wimbledon draw other than Novak Djokovic and Andy Murray with a Grand Slam tournament title to his name. He also won the Olympic bronze medal at the All England Club last summer.
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