Coach Gus Bradley said the Jaguars "feel good about what Chad has done the last few weeks" and "we just want to continue to build on that."
Henne threw for 318 yards in a 24-6 loss to San Diego, a second straight 300-yard performance. Blaine Gabbert "should be No. 2," according to Bradley.
Bradley said wide receivers Ace Sanders and Stephen Burton and defensive lineman Jeremy Mincey have been cleared to play after being limited by injury.
Wide receivers Cecil Shorts and Justin Blackmon did not practice Wednesday but will be available.
Jacksonville is 0-7 going into the second NFL International Series game at Wembley Stadium this season.
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