After conducting a major review of evidence, the agency said Tuesday it has ruled out any "potential risk of aspartame causing damage to genes and inducing cancer."
The finding will be welcome news to Coca Cola Co., which recently launched an advertising campaign to dispel fears about Diet Coke after other studies showed that aspartame might be dangerous, leading to a fall in sales.
Aspartame, the sweetener used in Diet Coke, is also known under the brand name NutraSweet.
The ESFA, the European Union's food risk assessment agency, is based in Parma, Italy.
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