Two strokes behind leaders Cristie Kerr and Lizette Salas entering the round, Nordqvist closed with her second straight 5-under 67 for a one-stroke victory over Salas.
Nordqvist won the LPGA Thailand last month to end a five-year victory drought, holding off top-ranked Inbee Park. The 26-year-old Swede also won the LPGA Championship and LPGA Tour Championship in 2009.
Projected to jump from 16th to ninth in the world, Nordqvist finished at 13-under 275 and earned $255,000.
Salas birdied the 18th for a 70.
Lexi Thompson was third at 11 under after a 68.
The Kraft Nabisco Championship, the first major tournament of the year, is next week in Rancho Mirage.
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