Ages of the victims were not immediately available, but at least one of the injured is a child, officials said.
The two-car collision occurred around 3:20 p.m. east of Fales Road. A stretch of the highway was expected to be closed for at least two hours while officers investigated, according to the Washington State Patrol.
The crash involved a Ford Fusion and a Mitsubishi Eclipse.
The driver of the Ford was taken to Harborview Medical Center in Seattle, but died from his injuries. His passenger, a woman, died at the crash scene.
The state patrol was working to notify family, trooper Keith Leary said.
The other car was driven by a man. The passenger was a child whose gender was not immediately available. Both were taken to Harborview.
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