The 31-year-old Cano asked manager Lloyd McClendon for the day off after playing all 28 innings in the Mariners' first two games after the All-Star break, a 16-inning loss followed by a 12-inning win.
Willie Bloomquist started at second base sixth time this season in place of Cano, who began Sunday batting .335 with seven home runs and 34 RBIs in 93 games.
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