Ivanovic, who had been having her best season since winning the French Open in 2008, lost to Karolina Pliskova 7-5, 6-4 in the second round Thursday.
Ivanovic had 47 match wins coming into Flushing Meadows, the most of any woman on the tour this year. But she was unable to find a rhythm against Pliskova, a tall, big-hitting Czech ranked No. 42. Ivanovic struggled repeatedly with first serves and sprayed 39 unforced errors off her ground strokes.
Ivanovic failed to advance to the third round of a Grand Slam event for the first time this year. She is the highest seed to fall after No. 4 Agnieszka Radwanska, who lost to Peng Shuai in the second round.
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