Yeast infection drug-miscarriage link is hinted in new study

CHICAGO — A prescription drug for yeast infections may increase chances for miscarriages when used early in pregnancy, a large study in Denmark suggests.

The 17-year study involved oral versions of fluconazole, available in pills or liquid. It doesn’t provide any proof of harm, although the drug has been linked with other problems when used in high doses in pregnancy.

The researchers looked at more than 1 million pregnancies in Denmark, comparing outcomes among women who used oral fluconazole and those who didn’t.

Women who used the drug during the first six months of pregnancy were almost 50 percent more likely than nonusers to have a miscarriage. Women at increased risk included those on a low 150-milligram dose; those on higher doses faced greater miscarriage risks.

While fewer than 10 percent of women in each group had miscarriages — they totaled 710 — the researchers said doctors should use caution in prescribing the drug early in pregnancy.

The study, by researchers at State Serum Institute in Copenhagen, was published Tuesday in the Journal of the American Medical Association.

Yeast infections are common among women and occur more often in pregnancy because of hormonal changes. Over-the-counter creams and suppositories, and prescription fluconazole, in pills or liquid, are among treatments. Fluconazole is available in generic versions and under the brand name Diflucan, typically prescribed in a single dose. Multiple high doses of fluconazole are sometimes prescribed for stubborn infections.

A U.S. Food and Drug Administration safety announcement in 2011 said those higher doses in early pregnancy may be linked with certain birth defects but that a single 150 mg-dose appeared safe. Research since then on possible risks from low-dose versions has had mixed results.

Recent U.S. studies show that oral fluconazole isn’t commonly prescribed during pregnancy.

Dr. Scott Sullivan, a member of the ethics committee at the American Congress of Obstetricians and Gynecologists, said the new study doesn’t prove any miscarriage risk from fluconazole, “it just means we need more data, more studies.”

Sullivan, an associate professor at the Medical University of South Carolina, said most oral medicines are used cautiously in women during the first 12 weeks of pregnancy because of concerns about potential risks.

Talk to us

> Give us your news tips.

> Send us a letter to the editor.

> More Herald contact information.

More in Local News

Traffic idles while waiting for the lights to change along 33rd Avenue West on Tuesday, April 2, 2024 in Lynnwood, Washington. (Olivia Vanni / The Herald)
Lynnwood seeks solutions to Costco traffic boondoggle

Let’s take a look at the troublesome intersection of 33rd Avenue W and 30th Place W, as Lynnwood weighs options for better traffic flow.

A memorial with small gifts surrounded a utility pole with a photograph of Ariel Garcia at the corner of Alpine Drive and Vesper Drive ion Wednesday, April 10, 2024 in Everett, Washington. (Olivia Vanni / The Herald)
Death of Everett boy, 4, spurs questions over lack of Amber Alert

Local police and court authorities were reluctant to address some key questions, when asked by a Daily Herald reporter this week.

The new Amazon fulfillment center under construction along 172nd Street NE in Arlington, just south of Arlington Municipal Airport. (Chuck Taylor / The Herald) 20210708
Frito-Lay leases massive building at Marysville business park

The company will move next door to Tesla and occupy a 300,0000-square-foot building at the Marysville business park.

Edmonds City Council members answer questions during an Edmonds City Council Town Hall on Thursday, April 18, 2024 in Edmonds, Washington. (Olivia Vanni / The Herald)
Edmonds fire service faces expiration date, quandary about what’s next

South County Fire will end a contract with the city in late 2025, citing insufficient funds. Edmonds sees four options for its next step.

House Transportation Subcommittee Chairman Rep. Rick Larsen, D-Wash., speaks during a hearing on Capitol Hill in Washington, Wednesday, May 15, 2019, on the status of the Boeing 737 MAX aircraft.(AP Photo/Susan Walsh)
How Snohomish County lawmakers voted on TikTok ban, aid to Israel, Ukraine

The package includes a bill to ban TikTok if it stays in the hands of a Chinese company, which made one Everett lawmaker object.

A grizzly bear is seen on July 6, 2011 while roaming near Beaver Lake in Yellowstone National Park, Wyoming. The National Park and U.S. Fish and Wildlife services have released a draft plan for reintroducing grizzlies into the North Cascades.
Grizzlies to return to North Cascades, feds confirm

Under the final plan announced Thursday, officials will release three to seven bears every year. They anticipate 200 in a century.

ZeroAvia founder and CEO Val Mifthakof, left, shows Gov. Jay Inslee a hydrogen-powered motor during an event at ZeroAvia’s new Everett facility on Wednesday, April 24, 2024, near Paine Field in Everett, Washington. (Ryan Berry / The Herald)
ZeroAvia’s new Everett center ‘a huge step in decarbonizing’ aviation

The British-American company, which is developing hydrogen-electric powered aircraft, expects one day to employ hundreds at the site.

"Unsellable Houses" hosts Lyndsay Lamb (far right) and Leslie Davis (second from right) show homes in Snohomish County to Randy and Gina (at left) on an episode of "House Hunters: All Stars" that airs Thursday. (Photo provided by HGTV photo)
Snohomish twin stars of HGTV’s ‘Unsellable Houses’ are on ‘House Hunters’

Lyndsay Lamb and Leslie Davis show homes in Mountlake Terrace, Everett and Lynnwood in Thursday’s episode.

Logo for news use featuring Snohomish County, Washington. 220118
Oso man gets 1 year of probation for killing abusive father

Prosecutors and defense agreed on zero days in jail, citing documented abuse Garner Melum suffered at his father’s hands.

Everett Mayor Cassie Franklin steps back and takes in a standing ovation after delivering the State of the City Address on Thursday, March 21, 2024, at the Everett Mall in Everett, Washington. (Ryan Berry / The Herald)
In meeting, Everett mayor confirms Topgolf, Chicken N Pickle rumors

This month, the mayor confirmed she was hopeful Topgolf “would be a fantastic new entertainment partner located right next to the cinemas.”

Alan Edward Dean, convicted of the 1993 murder of Melissa Lee, professes his innocence in the courtroom during his sentencing Wednesday, April 24, 2024, at Snohomish County Superior Court in Everett, Washington. (Ryan Berry / The Herald)
Bothell man gets 26 years in cold case murder of Melissa Lee, 15

“I’m innocent, not guilty. … They planted that DNA. I’ve been framed,” said Alan Edward Dean, as he was sentenced for the 1993 murder.

Gus Mansour works through timing with Jeff Olson and Steven Preszler, far right, during a rehearsal for the upcoming annual Elvis Challenge Wednesday afternoon in Everett, Washington on April 13, 2022. (Kevin Clark / The Herald)
Hunka hunka: Elvis Challenge returns to Historic Everett Theatre May 4

The “King of Rock and Roll” died in 1977, but his music and sideburns live on with Elvis tribute artists.

Support local journalism

If you value local news, make a gift now to support the trusted journalism you get in The Daily Herald. Donations processed in this system are not tax deductible.