Multiple sclerosis finding may change therapy strategy

Bloomberg News

NEW YORK — A cellular signature seen in the blood of multiple sclerosis patients may help determine their likelihood of relapse, potentially influencing which therapy physicians prescribe, a study found.

Differences in patients’ blood cells delineated them into two groups, one with a 40 percent lower risk of relapse, according to research today in the journal Science Translational Medicine. The findings eventually could help doctors determine whether to prescribe a drug such as Biogen Idec Inc.’s Avonex, which is moderately effective with fewer side effects, or its Tysabri, an aggressive therapy with greater safety issues, said Philip De Jager, a neurologist at Harvard Medical School in Boston and a study author.

Relapsing-remitting MS is the most common form of the illness, which affects more than 2.1 million people worldwide and about 400,000 Americans, according to the National Multiple Sclerosis Society. Patients with RRMS get attacks that degrade their neurological function, followed by periods of recovery.

“This study is a very important contribution to developing the kinds of tools that can help the physician personalize treatment,” said Timothy Coetzee, chief research officer of the National Multiple Sclerosis Society, in a telephone interview. “The challenge we’ve faced in MS is that for a physician there isn’t a blood test, like for your cholesterol level,” to provide information about the disease.

Doctors aim to be able to attack multiple sclerosis similarly to the way cancer is starting to be treated: by identifying the underlying cause of a patient’s tumor and selecting a drug tailored to attack it, said Coetzee, whose group is based in New York and Denver.

In MS, being able to determine a patient’s likelihood of flare-ups may lead doctors to prescribe a more aggressive treatment earlier, according to De Jager, who is also an MS specialist at Brigham and Women’s Hospital in Boston.

“If we had information about trying to predict the course of the disease, that would be very helpful for managing the patient’s care,” he said in a telephone interview.

The researchers drew on data from a study of the disease out of Brigham and Women’s, feeding information from 363 patients’ immune cells into a computer program that hunted for similarities. The analysis turned up two groups of patients, designated MS(a) and MS(b), separated by cellular differences and the likelihood of patients experiencing an exacerbation.

Patients in the MS(a) group expressed more genes in T-cell receptor and B-cell receptor pathways, which play roles in the immune system, and certain others, the researchers found. Those were the patients more likely to have an inflammatory event.

The groupings held regardless of whether a patient was taking interferon beta, such as Biogen’s Avonex; glatiramer acetate, or Teva Pharmaceutical Industries Ltd.’s Copaxone; or were untreated, the researchers found. Further studies are needed to determine whether a patient’s status remains the same or fluctuates over time, De Jager said.

Biogen, based in Weston, Mass., drew $2.7 billion in sales of Avonex last year and $1.1 billion for Tysabri.

The latter drug, given by infusion, is associated with a danger of contracting a brain infection called progressive multifocal leukoencephalopathy. Biogen has developed a test to help determine patients’ risk. The company has a pill for MS, BG-12, currently being weighed for approval by regulators.

In addition to Teva’s Copaxone, available MS therapies include Novartis’s Gilenya, the first pill approved for the disease; Sanofi’s Aubagio, another pill cleared earlier this month; Bayer’s Betaseron and Merck’s Rebif. More treatments are in development.

The next step after validating today’s study results is translating the findings into a clinical test, the MS Society’s Coetzee said.

“The notion of being able to tailor therapy based on a person’s transcriptional profile is very exciting for MS,” Coetzee said. “That’s the next frontier.”

More in Local News

Fatal car crash reported on Highway 92 near Lake Stevens

The 3 p.m. accident and investigation stopped traffic in both directions near Machias Road.

Firefighters come to the rescue and give mom new stroller

Donations to the Good Neighbor Program covered the $143.20 cost.

Mayor tries new tactic to curb fire department overtime

Stephanson says an engine won’t go into service when the only available staff would be on overtime.

Cheering families welcome Kidd, Shoup after 6 months at sea

“I get back Daddy back today,” said one homemade sign at Naval Station Everett.

Paine Field fire chief will be allowed to retire

In his letter, the airport director noted Jeff Bohnet was leaving while under investigation.

Stanwood man, 33, killed in crash near Marysville

Speed may have been a factor, the sheriff’s department said.

County plans to sue to recoup costs from ballot drop-box law

A quarter-million dollars could be spent adding 19 ballot boxes in rural areas.

County frees up $1.6M for Everett’s low-barrier housing

The plan appears on track for the City Council to transfer land ahead of next month’s groundbreaking.

Jamie Copeland is a senior at Cedar Park Christian Schools’ Mountlake Terrace campus. She is a basketball player, ASB president, cheerleader and, of course, a Lion. (Dan Bates / The Herald)
Cedar Park Christian senior stepping up to new challenges

Jamie Copeland’s academics include STEM studies, leadership, ASB activities, honor society.

Most Read