Irma Hendricks, who received a kidney transplant from a donor with hepatitis C, says she now has enough energy to play with her grandson, C.J. (Associated Press/Michael Rubinkam)

Irma Hendricks, who received a kidney transplant from a donor with hepatitis C, says she now has enough energy to play with her grandson, C.J. (Associated Press/Michael Rubinkam)

Transplant patients offered hepatitis-infected organs

  • By Lauran Neergaard Associated Press
  • Friday, November 18, 2016 11:44am
  • Life

By Lauran Neergaard

Associated Press

Some patients facing a yearslong wait for a kidney transplant are jumping ahead in line thanks to a startling experiment: They’re agreeing to an organ almost sure to infect them with hepatitis C.

Knowingly transmitting a dangerous virus may sound drastic, but two leading transplant centers are betting the strategy will save lives, if new medications that promise to cure hepatitis C allow use of organs that today go to waste.

Pilot studies are underway at the University of Pennsylvania and Johns Hopkins University to test transplanting kidneys from deceased donors with hepatitis C into recipients who don’t already have that virus. If the research eventually pans out, hundreds more kidneys — and maybe some hearts and lungs, too — could be transplanted every year.

“We always dreaded hepatitis C,” said Dr. Peter Reese, a Penn kidney specialist who is helping lead the research. “But now hepatitis C is just a different disease,” something to consider in what he calls a trade-off for getting a new kidney years faster but one that comes with a hopefully treatable infection.

It’s a trade-off prompted by the nation’s organ shortage. More than 99,000 people are on the national kidney waiting list, but only about 17,000 people a year get a transplant and 4 percent a year die waiting, according to the United Network for Organ Sharing.

“If we had enough organs, we wouldn’t do this,” said Dr. Niraj Desai, who is leading the Hopkins study. But, Desai said, “most patients are pretty open to the idea once they hear what the alternatives are.”

Doctors had told 66-year-old Irma Hendricks of East Stroudsburg, Pennsylvania, to expect at least a five-year wait for a kidney transplant. Dialysis three times a week was keeping her alive, but leaving her with no energy for even routine activities. “I call it the zombie syndrome,” she said.

She jumped at the chance to enroll in Penn’s study, even though doctors made clear they hoped for, but couldn’t guarantee a hepatitis cure.

“My son said, ‘Mom, this is a no-brainer. Just do it,’” Hendricks said.

She swallowed an anti-hepatitis pill daily for three months, in addition to the usual post-transplant medications. Testing showed the drugs rapidly cleared hepatitis C out of her bloodstream. With her new kidney functioning well, she now has enough energy to play with her toddler grandson.

“This is giving people in my situation new hope,” Hendricks said.

Kidney transplant specialists are closely watching the research.

“It makes sense to me,” said Dr. Matthew Cooper, a transplant surgeon at MedStar Georgetown University Hospital who is not involved in the research. He cautioned that the studies should use only kidneys that are young and otherwise high-quality, and that patients must understand the risks.

“They need to know you place their safety as the highest priority,” Cooper said. “But at the same time, recognize that we have these obstacles. We don’t want people to die on dialysis and there are not enough organs available for everybody.”

Hepatitis C is a simmering infection that, if untreated, can quietly destroy someone’s liver over two to three decades.

At least 2.7 million people in the United States have chronic hepatitis C. Until a few years ago, it was treatable only by medications with grueling side effects and poor cure rates. Now, breakthrough drugs promise to cure 95 percent of hepatitis C cases with fewer side effects — for people who can afford them. Treatment costs tens of thousands of dollars.

Normally, hepatitis C-infected organs are transplanted only into patients who already have hepatitis C themselves, so as not to further spread the virus.

Giving hepatitis C-positive organs to hepatitis C-negative recipients is allowed if the patient agrees, but it’s rare, said Dr. David Klassen, UNOS’ chief medical officer.

Statistics show a few dozen such transplants, mostly kidneys, last year, presumably when doctors feared their patients wouldn’t survive the wait for a healthier organ.

More often, hospitals discard hepatitis C-infected organs.

Reese and fellow Penn transplant surgeon Dr. David Goldberg found only 37 percent of hepatitis C-positive kidney donations between 2005 and 2014 were transplanted. The discards could have helped more than 4,000 patients during that time period, they reported in the New England Journal of Medicine last year.

The opioid epidemic is prompting a jump in donations from people who died of drug overdoses — typically young organs which, absent an infection risk, would be sought after.

Associated Press writer Michael Rubinkam contributed to this report.

Talk to us

More in Life

Flowering knotweed Persicaria amplexicaulis firetail in the morning light.
Save for one infamous variety, fleece flowers are easy to fall in love with

This long-blooming, easy-to-grow perennial comes in many desirable varieties. But watch out: One is an invasive knotweed.

A view of King Street Station in Seattle, Washington from an Amtrak Cascades train to Portland, Oregon from Everett, Washington on Wednesday, May 24, 2023. (Annie Barker / The Herald)
Ride the rails on Amtrak Cascades from Everett to Portland

Make new friends and let Amtrak do the driving on this 5-hour trip past sea, city and forest.

From left, Elora Coble, Carol Richmond, David Hayes, Karli Reinbold, Giovanna Cossalter Walters, Landon Whitbread in a scene from Edmonds Driftwood Players' production of "Murder on the Orient Express." (Dale Sutton / Magic Photography)
Music, theater and more: What’s happening in Snohomish County

Edmonds Driftwood Players opens its 65th season with Agatha Christie’s “Murder on the Orient Express.”

Local musician Alex Johnston, whose newest album "Daylight Fooldream" pairs with short film he made with help from his partner Mikaela Henderson, sits with his morning coffee on Friday, Sept. 15, 2023, at Narrative Coffee in Everett, Washington. (Ryan Berry / The Herald)
Folktronica musician shoots 37-minute visual album on iPhone in Everett

Alex Johnston, 31, describes his music as ”if Coldplay and Bon Iver had a love child.”

Some collectibles are found in nature; some imitate them. If it weren’t for the attached figure, this Royal Dux porcelain vase might pass for a real conch shell.
This shell-shaped vase would make a fine souvenir of summer fun

It may not be a real shell, but this art nouveau piece could still evoke fond memories of days at the beach.

Arlington Garden Club celebrating its 90th anniversary

The club has monthly programs for north Snohomish County gardeners and awards scholarships to area students.

Spouses Franchesca and Don Simpson talk about their baby girl’s “chubby cheeks” and “button nose” as Kelly Fox RDMS RVT performs a live-view 3D ultrasound on the expecting mother Saturday, August 26, 2023, at Wonder Baby Ultrasound Studio in Everett, Washington. The Simpsons are expecting their first child in October. (Ryan Berry / The Herald)
Glamour shots in utero? Everett studio offers HD ultrasound keepsakes

For curious parents, these glimpses are exciting, but not medically endorsed.

An Oxford White grille with red “BRONCO” lettering signifies the 2023 Ford Bronco Sport Heritage Limited Edition model. (Ford)
2023 Ford Bronco Sport has two new Heritage Edition models

Design and paint treatments pay homage to the original Bronco introduced in 1966.

Everett comedian Taylor Clark performs stand-up in 2023 at The Triple Door in Seattle, Washington. (Photo by Mike Bryk)
Comedian Taylor Clark to film first special Friday in Everett

The skateboarding funny-man will record an hour of his stand-up at the Historic Everett Theater.

Most Read