Best Phentermine Diet Pills (Top Alternative OTC Supplements)

Phentermine is a prescription weight-loss drug with powerful effects.

Today, some supplements replicate the effects of phentermine, making it easier for you to lose weight. These phentermine alternatives offer many of the same benefits as phentermine – and they don’t require a prescription.

Many weight loss supplements claim to replicate the effects of phentermine. However, only the top-rated phentermine supplements have been proven to help you lose weight.

What are the best phentermine alternative supplements? Which phentermine weight loss pill is right for you? Can a supplement truly replicate the effects of phentermine? Please keep reading to discover everything you need to know in our phentermine guide.

The Best Phentermine Alternative Supplements in 2022

After much deliberation within our editorial team, here’s how we ranked the best phentermine alternative supplements you can legally buy without a prescription in 2022.

  • PhenQ
  • PhenGold
  • Phen24
  • PhenAprin
  • Phena-Lean


PhenQ is a combination of five weight loss ingredients in one convenient formula. Instead of taking five supplements to help you lose weight, you can take one powerful supplement.

Backed by 190,000 customers, PhenQ is one of the best-selling weight loss pills sold online today. According to the manufacturer, PhenQ will help you get the body you’ve always wanted while also delivering benefits like appetite suppression, improved mood and energy levels, and increased fat burning.

Key ingredients in PhenQ include alpha-Lacys Reset, a proprietary ingredient that accelerates your metabolism, which means you naturally burn more calories at rest. This ingredient turns up your body’s internal thermostat, accelerating fat burning.

Other active ingredients in PhenQ include Capsimax (a blend of caffeine, piperine, capsicum, and niacin), chromium, caffeine, nopal, and L-carnitine. Together, these ingredients deliver proven fat-burning benefits. One customer claims she lost 44lbs in 3 months by combining PhenQ with a healthy diet and exercise program. The PhenQ diet pills are the best Phentermine alternative supplement to buy in 2022 for all these reasons, and they even make one of the best meal replacement shakes too in the PhenQ Meal Shake for those who want a dynamic one two punch!


PhenGold is a multi-action weight loss formula that aims to give you actual, lasting weight loss by burning fat, reducing cravings, boosting metabolism, and improving mood and energy.

Featuring clinically proven ingredients, PhenGold is marketed to anyone who wants to jumpstart their weight loss goals, breakthrough frustrating plateaus, or hit their target weight. According to PhenGold.com, customers have lost anywhere from 21lbs to 30lbs after taking PhenGold for three months.

To achieve these weight loss benefits, PhenGold switches on specific fat-burning hormones. These hormones tell your body to break down and burn stored fat. The combination of ingredients in PhenGold includes caffeine, L-tyrosine, Rhodiola, green tea, and capsaicin.

PhenGold is made in the United Kingdom by a company named Swiss Research Labs Limited. The company offers full refunds with every order.


Phen24 is a metabolism-boosting supplement that raises thermogenesis 24 hours a day – even while you sleep. Phentermine is more of an appetite suppressant than a thermogenic, yet some of the most popular phentermine alternative supplements target metabolism instead of appetite.

By taking Phen24 daily, you can purportedly enjoy a “metabolism fueling system” that heightens thermogenesis “even while you sleep.” That means your body stays in fat-burning mode 24/7, supporting your weight loss goals around the clock.

Many overweight people have a slow metabolism. Fat burns fewer calories than muscle, so your body burns fewer calories at rest than a lean person. That gives overweight people an unfair disadvantage for weight loss. Phen24 aims to help by kickstarting your metabolism over 24 hours.

Phen24 contains some of the most popular and proven metabolism boosters on the market, including caffeine, guarana extract, and cayenne powder. Priced at $75 per box, it’s also one of the more expensive phentermine alternative supplements on our list – but all purchases come with fast and free shipping and are backed by a 60-day money-back guarantee.

Best Phentermine Alternatives on Amazon

We applied the same ranking factors to the top-rated phentermine supplements on Amazon. Here’s what we found.


PhenAprin from SutraHealth is an advanced weight loss formula to help maintain and curb appetite. Available at a discount price of $40 on Amazon, PhenAprin may be the best-value phentermine alternative supplement on our list.

PhenAprin claims to support rapid fat loss in men and women by acting as a potent appetite suppressant. The formula also claims to boost energy, enhance mood and focus, and increase the chances of hitting your target weight, among other benefits.

To achieve these benefits, PhenAprin uses L-phenylalanine, theobromine, caffeine, L-taurine, and L-carnitine, among other ingredients. With 540mg of a proprietary formula per pill, PhenAprin competes with the higher-rated options on our list in terms of weight-loss effectiveness – and the price is impossible to beat.


Phena-Lean is a phentermine alternative supplement from Anabolic Warfare. Backed by an average rating of 3.8 stars and 1,000+ reviews on Amazon, Phena-Lean is one of the best-rated options on our list (most weight loss supplements don’t have ratings higher than 4.0 stars).

Key ingredients in Phena-Lean include vitamin B3, caffeine, L-theanine, L-tyrosine, and ginseng. Each bottle contains 60 servings. The manufacturer recommends taking two capsules daily to suppress appetite, increase energy, boost metabolism, and burn stubborn fat.

Phena-Lean may be the right choice for those seeking to cut fat and preserve muscle. According to Anabolic Warfare, the diet pill is a “sculpting agent” that has muscle-preserving properties. You’ll drop fat without burning lean muscle mass, something that we don’t see with other phentermine alternative supplements listed here.

How We Ranked The Best Phentermine Alternative Supplements

Any phentermine alternative diet pill supplement can claim to help you lose weight. However, we separated the claims from the facts using the following ranking factors (and hundreds of hours of research):

Science-Backed Weight Loss Ingredients

Some natural ingredients have been genuinely proven to help with weight loss. Some elements block your appetite, for example. Others boost your metabolism. Coffee, for example, has been shown to raise your basal metabolic rate, which is the number of calories your body burns at rest. The best phentermine alternative supplements contain science-backed ingredients shown to help with weight loss.

Effective Dosages

Some phentermine alternative supplements had the right ingredients but the wrong dosages. For example, they had ten proven weight loss boosters yet used small doses of all listed components. We preferred phentermine alternative supplements with proven ingredients and effective dosages.

Realistic Weight Loss Claims

Even with phentermine, you won’t lose 30lbs in a week. We were wary of phentermine alternative supplements that made unrealistic weight-loss claims. If a supplement claims you can lose weight without dieting or exercising, it’s probably a scam. The best phentermine alternative supplements work in conjunction with a healthy diet and exercise program.

Advertised Benefits

Per FDA regulations, supplement companies cannot advertise products as a treatment, cure, or preventative measure for the disease. They also cannot claim to offer the same health benefits of a prescription drug – like phentermine. We were wary of phentermine supplements that exaggerated their claims or toed the line of FDA regulations.

Manufacturer Reputation

Some supplement companies have a proven reputation for creating effective weight loss supplements over the past few decades. Other weight loss supplement companies are new and unproven. Some are downright scams. We preferred manufacturers with a proven reputation for creating quality supplements.

Price & Value

Some people are willing to spend $150 on a weight loss supplement. Others want to spend $10. Whatever your budget may be, we want you to get good value for your phentermine alternative supplement. We considered price and value in our rankings to ensure you got good budget ones – or premium ingredients in premium formulas.

Lab Testing and Third-Party Verification

The best supplement companies invest in third-party lab testing. Labs test their formulas to verify they’re free of toxins, metals, and unlisted substances. Many supplement companies, however, avoid lab testing to save money. Lab testing and third-party verification were crucial in the phentermine supplement space, as there are many sleazy companies in the weight loss pill industry. Some companies have been caught sneaking real phentermine and other weight loss drugs into their supplements, which is why lab testing is essential.

Created by Doctors or Other Health Professionals

Medical doctors (MDs), certified nutritionists, or dietitians formulated the best phentermine alternative supplements. These professionals have a proven reputation for creating effective formulas, using their experience to combine the perfect ingredients. We were wary of phentermine alternative supplements that did not list a medical advisory board or similar professional body.

Money-back or Satisfaction Guarantee

If you don’t lose weight with a diet pill, you should be able to request a refund. The best phentermine alternative supplements backed up their claims with a money-back or satisfaction guarantee. Some even had a 180 or 365-day refund policy, making it easy to request a refund if you don’t like the results.

What is Phentermine?

Phentermine is a weight loss medication approved by the FDA in 1959. It’s available only with a prescription.

Phentermine surged in popularity in the 1990s. People combined phentermine with other drugs to safely and quickly lose weight. However, after reports of heart problems in users, the FDA pulled the two other drugs from the market (fenfluramine and dexfenfluramine).

Adipex-P, Lomaira, and Suprenza are some of the most common brand names for phentermine. Qysmia, a weight-loss drug with multiple ingredients, also contains phentermine.

How Does Phentermine Work?

Phentermine is an appetite suppressant. It blocks your appetite and reduces feelings of hunger, helping you naturally eat less.

When you feel less hungry, you eat fewer calories. By maintaining a caloric deficit, you can lose weight with phentermine.

Phentermine targets neurotransmitters in the brain to suppress your appetite.

Researchers don’t fully understand how phentermine interacts with these neurotransmitters. However, it appears to raise levels of serotonin, dopamine, and norepinephrine. Your body typically produces these neurotransmitters after eating. By increasing these neurotransmitters, phentermine can trick your body into thinking it has already eaten, reducing your hunger.

How to Get a Phentermine Prescription

Doctors may prescribe phentermine if you’re obese.

However, because phentermine has chemical similarities to the stimulant amphetamine, it’s a controlled substance available only with a prescription.

Doctors may prescribe phentermine if you’re obese and have other health conditions related to your weight, like high blood pressure, diabetes, or high cholesterol.

Talk to your doctor if you feel phentermine diet pills are the right choice for you. A doctor can help you make an informed decision based on your health and weight loss goals.

Who Should Take Phentermine Alternative Supplements?

Phentermine alternative supplements are marketed to anyone who wants to lose weight.

Some of the people who could benefit from phentermine alternative supplements include:

  • Anyone trying to jumpstart weight loss
  • Someone trying to break a frustrating plateau
  • Anyone trying to hit their target weight or reach a specific weight loss goal
  • Anyone who wants to look and feel their best

Side Effects of Phentermine Alternative Supplements

Most healthy adults experience no side effects when taking phentermine alternative supplements in standard dosages.

Per FDA regulations, phentermine alternative supplements must contain ingredients and dosages that are generally recognized as safe (GRAS). These ingredients have been determined to be safe for most healthy adults to take.

However, some people experience mild side effects like:

  • Nausea
  • Headache
  • Digestive discomfort (constipation or diarrhea)

These side effects are rare.

Phentermine is a controlled substance because it has a chemical structure similar to amphetamine. However, phentermine alternative supplements have no relation to phentermine: they’re supplements with safe, natural ingredients and not a prescription drug.

However, talk to your doctor before taking phentermine alternative supplements if you take medication or have any health condition.

Phentermine Alternative Supplement Dosage

Phentermine has been shown to work at doses of around 27.5mg. For example, in this review, researchers found that an average amount of 27.5mg of phentermine was associated with an average weight loss of 13.9lbs over 13 weeks.

Phentermine alternative supplements, however, contain a range of ingredients with different concentrations and dosages. They don’t include phentermine: they have other weight loss ingredients.

Because supplements contain different dosages and ingredients, follow the instructions on your alternative phentermine diet pills. With most supplements, you take one or two capsules (or one or two scoops of powdered formula) daily to support your weight loss goals.

Check the caffeine dosage in your phentermine alternative supplement. Some contain 200mg to 300mg of caffeine, which could be a problem for caffeine-sensitive individuals. The average cup of coffee contains 80mg to 120mg of caffeine. A single serving of a phentermine alternative supplement may be like taking three cups of coffee at once.

How Much Weight Can You Lose?

People lose 5% to 10% of their body weight when taking phentermine diet pills.

In other words, people who weigh 200lbs can lose 10lbs to 20lbs when taking phentermine.

In a similar review study analyzing six trials on phentermine, researchers found that participants lost an average of 13.9lbs over 13 weeks when taking phentermine.

Phentermine alternative supplements aren’t as powerful, but you can still lose a significant amount of weight – especially when combined with a diet and exercise program.

According to some phentermine alternative supplements, customers lost 30lbs to 60lbs in a short period by adding the supplement to their regimen.

Although you should be skeptical of exaggerated weight-loss claims, anyone can lose weight – and keep it off – by taking a phentermine alternative supplement while dieting and exercising.

You could enhance the weight loss effects of phentermine by combining it with other weight loss drugs – like topiramate. Topiramate is an anti-seizure drug but, when combined with phentermine, reduces hunger.

One study found that a combination of phentermine and topiramate led to an average weight loss of 21.6lbs over one year, making it one of the most effective weight loss drugs on the market.

Benefits of Phentermine

Phentermine is a prescription medication associated with a range of benefits. It’s primarily used for weight loss, although studies have observed various other benefits related to phentermine.

Studies show that phentermine can provide all of the following benefits:

  • Improved insulin sensitivity
  • Significant decreases in waist circumference
  • Weight loss
  • Better blood sugar control
  • Better cholesterol
  • Possibly helpful for some eating disorders

Phentermine diet pills aren’t associated with the same benefits. However, good phentermine supplements can support weight loss when combined with diet and exercise.

Clinical Trials on Phentermine: What Does Science Say?

Researchers have observed the benefits of phentermine in many clinical trials. Research shows that phentermine can support all of the benefits listed above.

In this study, researchers found that people lost as much as 10% of their body weight over 12 weeks while taking phentermine.

Meanwhile, a similar study on the weight loss benefits of phentermine found that people lost an average of 13.9lbs when taking 27.5mg of phentermine over 13 weeks.

Some doctors recommend pairing phentermine with topiramate to maximize weight loss benefits. You can also find this combination sold under the brand name Qsymia. In this study, researchers found that phentermine worked better when combined with topiramate. A separate study found that phentermine and topiramate gave participants the highest odds of losing at least 5% of their body weight.

Because of the weight loss effects of phentermine, researchers have observed several health benefits linked to phentermine. This study found that participants had smaller waist circumference, better insulin sensitivity, and improved blood sugar control after taking phentermine. In another study, participants lowered cholesterol levels when taking phentermine.

Doctors may prescribe phentermine to people with eating disorders. In this 12-week study, researchers gave phentermine to a group of people with binge eating disorder (BED). A combination of phentermine and topiramate led to significant reductions in weight, body mass index, and episodes of binge eating. In a similar study, participants reduced the average number of binge eating days from 16.2 to 4.2 after 28 days of treatment with phentermine and topiramate.

Whether you’re taking phentermine or a phentermine alternative supplement, you’ll lose more weight if you follow healthy diet and lifestyle strategies. Science tells us that the best ways to lose weight include:

  • Follow a reduced-calorie diet. Eat 300 to 500 fewer calories per day than you usually would lose weight consistently.
  • Choose nutrient-dense, low-calorie foods. Fruits and vegetables are low in calories and rich in vitamins and nutrients. Choose foods rich in fiber, vitamins, and minerals to maximize weight loss results and increase feelings of fullness.
  • Get more exercise. Experts recommend 150 minutes of moderate aerobic activity per week to stay healthy. Adding exercise to your routine will help you lose weight when taking phentermine or phentermine alternative supplements.
  • Make behavioral changes. Making behavioral changes isn’t easy, but it’s the best way to enjoy long-term weight loss. Monitor your food intake, track your exercise habits, and make other adjustments to your behavior to lock in your weight loss.

Research shows that phentermine is generally safe to take. However, researchers have observed some side effects, including dry mouth, sleeping problems, dizziness, heart palpitations, skin flushing, fatigue, constipation, and irritability. Additionally, you should not take phentermine if you have heart disease, hyperthyroidism, or if you’re pregnant or nursing.

How Do Phentermine Alternative Supplements Work?

Phentermine diet pills and alternative supplements have no connection to phentermine. They’re not chemically similar to phentermine, nor are they made by the same company. However, good phentermine alternative supplements, like phentermine, can help you lose weight.

Phentermine alternative supplements contain proven weight loss boosters like caffeine, green tea extract (found in Java Burn), Oleuropein (found in Exipure), and capsaicin. Some contain appetite-suppressing ingredients like fiber.

Caffeine is one of the most proven weight loss supplement ingredients. Many people take caffeine daily without considering its weight loss benefits. Caffeine is proven to boost metabolism, helping you burn more calories at rest. There’s a reason nearly every phentermine alternative supplement above contains caffeine: it’s one of the most proven ways to support fat burning and weight loss. Some phentermine-like supplements above contain 200mg of caffeine or more, roughly the equivalent of two cups of coffee.

Instead of analyzing each caffeine weight loss study, it helps to look at this 2019 review. In that review, researchers analyzed dozens of randomized controlled trials on caffeine and weight loss. Researchers found that caffeine significantly reduced weight, fat mass, and BMI, with participants losing 17% to 28% more weight than placebo treatments. Researchers also found that as caffeine intake doubled, participants lost twice as much weight.

Many phentermine alternative supplements above also contain capsaicin, the active ingredient in cayenne pepper. This ingredient has been linked to excellent weight loss in multiple studies. In this 2017 study, for example, researchers found that dietary capsaicin was linked to anti-obesity effects, making it a solid potential treatment for obesity. Similarly, this 2018 study found that capsaicinoids supplements reduced body fat and fat mass. Capsaicin appears to work by raising metabolism and inducing thermogenesis, boosting calorie burning and making it easier to lose weight.

One of the best ways to suppress your appetite (like phentermine) is by taking a fiber supplement. Fiber soaks up water in your stomach, tricking you into feeling full. There’s a reason many weight loss experts recommend taking fiber for weight loss. In this 2019 study, researchers found that fiber intake made it easier for adults to stick to calorie-restricted diets. Adults found it easier to stick to a low-calorie diet and lose weight by taking a fiber supplement.

Overall, you can find plenty of phentermine-like ingredients in the natural world. These ingredients can suppress your appetite and make it easier to achieve your weight loss goals.

FAQs About Phentermine Alternative Supplements

We get plenty of questions about phentermine, phentermine alternative supplements, and weight loss. Here are some of our most commonly answered questions.

Q: How much weight do you lose the first week on phentermine?

A: Studies show you can lose up to 7lbs the first week on phentermine as your body adjusts to the drug.

Q: How much weight can I lose with phentermine?

A: Generally, studies show that people lose 5% to 10% of their body weight after taking phentermine for 3 to 4 months.

Q: How long do I take phentermine before seeing results?

A: Phentermine takes effect within 3 to 5 hours after ingestion. You should start to feel the appetite suppression benefits of phentermine begin around this time. As long as you stick to a healthy diet and exercise program, you can start losing weight within the first few days of taking phentermine, with some people losing up to 7lbs their first week.

Q: Can I drink caffeine with phentermine?

A: Both phentermine and caffeine are stimulants, and both can cause insomnia, increased heart rate, and jitters. Some people take both to accelerate weight loss results. However, be careful when mixing phentermine and caffeine.

Q: Can you lose 20lbs in a month on phentermine?

A: Studies show you lose 5% to 10% of your body weight when taking phentermine over a 3 to 4 month period. It’s possible to lose 20lbs in a month, especially if you’re starting at a higher initial weight.

Q: Does phentermine change your taste?

A: Phentermine can leave you with a bad taste in your mouth. It’s one of the common side effects of phentermine. However, there’s no evidence phentermine will permanently change your taste buds.

Q: What are the side effects of phentermine?

A: Side effects of phentermine may include nausea, vomiting, diarrhea, dry mouth, and constipation.

Q: Can I exercise while taking phentermine?

A: Yes, you can exercise while taking phentermine, and you should exercise to boost weight loss results.

Q: Why am I still hungry after taking phentermine?

A: Phentermine suppresses appetite, but it doesn’t remove the appetite altogether. You may need to adjust your diet or increase your phentermine dose.

Q: Can I take two doses of phentermine per day?

A: Follow your doctor’s recommended treatment plan for your phentermine. Generally, you should not take two doses of phentermine at one time.

Q: What is phentermine?

A: Phentermine is a prescription weight-loss drug designed to suppress appetite, making it easier to lose weight.

Q: How does phentermine work?

A: Phentermine raises levels of neurotransmitters in the brain linked to hunger, including dopamine, serotonin, and norepinephrine.

Q: Do I need a prescription for phentermine?

A: Yes, you need a prescription to buy phentermine.

Q: How much does phentermine cost?

A: Phentermine costs around $36 for a one-month supply.

Q: Does insurance cover phentermine?

A: Most insurance does not cover phentermine.

Q: What is fen-phen?

A: Fen-phen was an off-label combination of fenfluramine and phentermine designed to maximize the weight loss effects of phentermine. The FDA banned fenfluramine from the market after reports of heart failure.

Q: Is phentermine legal?

A: Yes, phentermine is a legal, controlled weight loss medication available via prescription.

Q: Why do I need a prescription for phentermine?

A: You need a prescription for phentermine because it’s chemically similar to amphetamine, and it works similar to amphetamines. Because of this similarity, there’s the potential for abusing phentermine.

Q: Is phentermine addictive?

A: Although some believe that phentermine is addictive because of its chemical similarity with amphetamines, one 2013 study found that patients experienced no withdrawal even after decades of taking phentermine, suggesting that phentermine is not addictive.

Q: How do I take phentermine?

A: You take phentermine as a tablet or capsule.

Q: Is phentermine good for weight loss?

A: Phentermine is one of the most popular and most-prescribed weight loss medications available today.

Q: What is a phentermine alternative supplement?

A: A phentermine alternative supplement is a nutritional supplement that seeks to replicate the effects of phentermine, a prescription weight loss drug.

Q: How do phentermine alternatives work?

A: Phentermine alternatives use natural ingredients, vitamins, minerals, and nutrients to help you lose weight.

Q: What do phentermine alternative supplements do?

A: A good phentermine alternative supplement can suppress your appetite, block hunger, boost metabolism, and help you achieve your weight loss goals.

Q: Are phentermine alternative supplements legal?

A: Yes, phentermine alternative supplements are legal for anyone to take – just like any other supplement. They contain no banned ingredients and no controlled substances.

Q: Where do I buy phentermine supplements?

A: Phentermine is a controlled drug available only via prescription from a doctor. There are no phentermine supplements, although you can find phentermine alternative supplements that seek to replicate the effects of phentermine.

Q: What are the brand names for phentermine?

A: Brand names for phentermine include Adipex-P, Suprenza, and Lomaira.

The Best Phentermine Alternative Supplements in 2022 Final Word

Phentermine is one of the most popular and proven weight loss drugs ever released. Phentermine can help you lose a significant amount of weight in a short period.

If you want to support similar benefits to phentermine without a prescription or side effects, consider any phentermine supplements listed above.

As a final review of the best Phentermine supplements to pick as viable alternatives, here is the list one more time as the top choices to buy:

  • Best Phentermine alternative supplement to buy in 2022
  • Clinically-proven ingredients that act as great Phentermine replacements
  • Best Phentermine supplement for boosting metabolism
  • Best Phentermine supplement alternative on Amazon
  • High quality ingredients and excellent customer reviews on Amazon.com

And that’s it folks! Phentermine alternative supplements are legal for anyone to purchase and contain proven, popular ingredients to help you lose weight. Now that the entire best Phentermine diet pills review is over and everyone can see the top ranking weight loss alternatives, now the only thing left to do is make a decision which of these most popular, highly regarded formulas is right for you!


The news and editorial staff of Sound Publishing, Inc. had no role in the preparation of this post. The views and opinions expressed in this sponsored post are those of the advertiser and do not reflect those of Sound Publishing, Inc.

Sound Publishing, Inc. does not accept liability for any loss or damages caused by the use of any products, nor do we endorse any products posted in our Marketplace.

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