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Best Mushroom Supplements: Top Medicinal Mushroom Products of 2022

Medicinal mushrooms have never been more popular due to their medicinal properties.

Scientists continue to discover new psilocybin benefits – and consumers are starting to notice. Today, it’s easier than ever to buy medicinal mushrooms and mushroom supplements online.

Most mushroom supplements do not contain psilocybin because it’s a controlled substance. Instead, mushroom supplements contain other types of mushrooms with proven benefits.

From medicinal mushrooms to mushroom supplements and more, you have more choices than ever as we have selected the best medicinal mushroom formulas of the year. Here are our top 29 mushroom supplements of 2021.

Ranking the Best Medicinal Mushroom Supplements in 2021

Onnit Shroom Tech Support Helps one to have better cellular energy and boost physical performance
Four Sigmatic Promotes focused energy
Real mushrooms Supports immunity and brain health
MUD/WTR Boost cardiovascular health and lowers down blood sugar level
Mushroom Defense Promotes a healthy immune system and cognitive health
Organixx 7m +Maintains immunity and enhances energy levels
Pure Essence MyPure Lion’s mane mushrooms Calms and relaxes the mind
Genius Mushrooms Energizes body and mind for proper functioning
Mushroom Revival Boost mental health and clarity
Earth Nutri Performance Energy + Focus Increases energy level and helps in attaining better focus and alertness
FreshCap Supports digestive and gut health
VidaCap Aids in weight loss and ensures better sleep quality
Shroomy Enhances cognitive health
Ceremony Mushrooms Supports healthy immune function and muscle mass
GundryMD Mushroom Vitality Increases focus and energy level
Circadian Wellness Promotes overall health and wellbeing
VitaPost immune Support Enhances Immunity and boost energy levels
MycoPhyto Complex Promote a relaxed mind and better brain performance
Brain Forza Organic’s Lion Mane Mushroom Calms mind and works as a great body defense system magic Mushroom Avoids bacterial and viral infections
Spore Works as a brain booster
Vital Plan adaptogenic Mushrooms Maintains energy levels and supports heart health
The Drug Store Adaptogenic mushrooms Reduces stress and depression related symptoms
Botany Cordyceps Militaris Extract Enhances blood flow for better immune function
Plant people wonder day Eliminate age related body decline
5 Mushrooms Reserve blend Ensures healthy overall health and wellbeing
MindHoney Enhances mental performance
Vitan Plan Brain Boost Works as a great immunity booster

Our editorial team contacted manufacturers, analyzed lab reports, and compared the top mushroom supplements available today. After extensive deliberation, here is our ranking of the best 29 mushroom supplements of 2021:

Onnit Shroom Tech SPORT


Onnit is one of the best mushroom supplements with excellent results. The Joe Rogan-backed supplement company advertises Shroom Tech SPORT as a daily energy supplement. By taking one capsule of Shroom Tech SPORT daily, you can support daily energy in multiple ways.

We like the Onnit Shroom Tech SPORT because it’s one of the best mushroom supplements on this list, backed by a clinical trial. Onnit has invested in clinical trials for Shroom Tech SPORT and other supplements. In one trial, Shroom Tech SPORT increased bench press reps by 12%, improved bench press and back squat reps by 7%, and improved cardio performance by 8.8%.

Shroom Tech SPORT works by giving you plant-based ingredients, vitamin B12, and a mushroom complex to support energy in various ways. The powerful composition makes it the best medicinal mushroom formula on our list.

Ingredients Cordyceps, Adaptogen blend, ashwagandha, green tea leaf extract, Rhodiola, and astragalus root extract
Key Highlights
  • Helps in assisting cellular energy
  • Boost physical performance
  • Promotes exercise volume
  • Increases oxygen utilization
  • Price $25
    Other Perks
  • 100% natural formula
  • 10% off on first order
  • Soy and gluten-free formula
  • Keto-friendly product
  • Four Sigmatic


    Four Sigmatic has been featured in several major media outlets for its coffees and vegan proteins. Goop, Women’s Health, and TIME have all covered Four Sigmatic supplements. Four Sigmatic combines the benefits of mushroom extracts with other plant-based ingredients.

    Four Sigmatic separates its mushroom supplements into three main categories, including ‘Think’ (for focused mornings and afternoons), ‘Defend’ (for daily nutrition, immune, and gut support), and ‘Chill’ (for relaxation at any time). You can also shop by product type, choosing from coffees, proteins, and Caicos, among other options.

    Four Sigmatic is based in Finland, where people have used mushrooms like Chaga and lion’s mane for centuries. Popular Four Sigmatic mushroom supplements include the Mushroom Blend Mix, ground mushroom coffees, and plant-based protein powders in multiple flavors. Four Sigmatic products are also USDA Organic certified, making Four Sigmatic one of the best medicinal mushroom companies and supplement providers available today.

    Ingredients Organic Superfood Protein Blend (organic pea protein, organic hemp, organic chia, organic coconut, and organic pumpkin protein powders), Organic Ashwagandha, Organic Eleuthero, Organic Lion’s Mane, Organic Turkey Tail, Organic Cordyceps, Organic Reishi, Organic Chaga, Organic Lucuma
    Key Highlights
  • Supports immune system
  • Improves your sleeping habits
  • Increases your energy level
  • Maintains a good body mass index
  • Price $20+
    Other Perks
  • Gluten and Soy free product
  • 100% organic formula
  • No side effects
  • Easily available online
  • Real Mushrooms


    Real Mushrooms is a family-owned and operated mushroom farm and supplement company. Backed by 40 years of mushroom growing experience, Real Mushroom has more real-world expertise than many companies on this list combined.

    Popular Real Mushrooms formulas include capsules and powders, well known as the best mushroom mix for overall health and wellbeing. You can choose specific mushroom capsules and powders. Or, you can select a blend of multiple mushroom extracts like ‘5 Defenders’ or ‘Mushroom Hot Chocolate Mix,’ among other popular options.

    IngredientsChaga, tremella, turkey tail, reishi mushrooms, and cordyceps mushrooms
    Key Highlights
  • Boost brain performance
  • Enhances cardiovascular health
  • Promotes better immune system
  • Improves brain’s productivity
  • Price$25 to $35
    Other Perks
  • Free shipping all over the world
  • No sweeteners or fillers are added
  • Free educational sources
  • Made from certified organic mushrooms


    MUD\WTR is a coffee alternative that uses organic ingredients to deliver targeted benefits. The goal of MUD\WTR is to give you the energy-boosting benefits of coffee without overloading your body with caffeine.

    If you want to give your body a boost of energy in the morning without the jitters or unpleasant side effects of caffeine, then MUD\WTR may be the right choice for you. Each serving contains 1/7 the caffeine of coffee.

    Ingredients Masala chai, cacao, turmeric, cinnamon, Himalayan sea salt, and four types of real mushrooms: lion’s mane, cordyceps, chaga, and reishi.
    Key Highlights
  • Energy-boosting mushroom supplement
  • Improves immune function and digestive system
  • Supports memory and focus
  • Increases physical performance
  • Price $40
    Other Perks
  • USDA certified organic ingredients
  • Attractive taste and flavor
  • Easy to prepare
  • Made under GMP using practices
  • Mushroom Defense


    Mushroom Defense is one of the best mushroom supplements that fight fatigue and shield against cognitive decline while providing other protective benefits. According to the manufacturer, Mushroom Defense can give you a clean and energized feeling, protect against viral and bacterial threats, and sharpen your memory and focus, among other unique benefits we don’t see advertised with other mushroom supplements.

    The mushrooms added in Mushroom Defense come from a mix of 80% fruit bodies and 20% mycelium, described as ‘revolutionary’ by the manufacturer.

    Ingredients cordyceps, lion’s mane, turkey tail, shiitake, and maitake mushroom extracts
    Key Highlights
  • It keeps you energetic throughout the day
  • Boost immune system to avoid viral infections
  • Boost mental and cognitive health
  • Reduces the risk of age-related decline
  • Price $60
    Other Perks
  • 67 days money-back guarantee
  • Easy and convenient to consume
  • 100% natural formula
  • Vegetarian and gluten-free
  • Organixx 7M+


    Organixx 7M+ is one of the immune-boosting fermented medicinal mushroom supplements that consists of a blend of seven potent mushrooms known for their immune-supporting and anti-aging properties. All medicinal mushroom extracts are added to the composition. Each mushroom has been fermented for maximum nutrition and bioavailability.

    Organixx 7M+ mushroom complex has also added a unique ingredient we don’t see with other mushroom supplements: kelp extract. The kelp extract in 7M+ can purportedly support healthy liver function.

    Ingredients Turkey tail, chaga, shiitake, maitake, cordyceps, lion’s mane, and reishi mushrooms
    Key Highlights
  • One of the best mushroom supplements to calm the mind and reduce stress
  • Immune-boosting properties
  • Eliminate age-related decline symptoms
  • Ensures a healthy liver and digestive system
  • Price $55
    Other Perks
  • The clinically proven medicinal formula
  • Manufactured under FDA approved facilities
  • Complete safe product
  • GMO-free formula
  • Pure Essence MyPure Lion’s Mane


    Pure essence mypure Lion’s mane is one of the best medicinal mushroom supplements available today. With MyPure Lion’s Mane, you get a significant dose of lion’s mane in each capsule. Pure Essence markets MyPure Lion’s Mane to support healthy brain function and immune response. By taking one pill of MyPure Lion’s Mane daily, you can purportedly support memory, mood, cognizance, nerve growth, healthy brain function, and more.

    The Pure Essence MyPure Lion’s Mane has another advantage over the competition: the supplement is made from 100% certified organic lion’s mane mushroom extract.

    Ingredients Lion’s mane extract
    Key Highlights
  • Supports healthy immune system
  • Enhances brain and cognitive health
  • Offers healthy nerve growth
  • Enhances memory power
  • Price $23
    Other Perks
  • 90 days money-back guarantee
  • Certified organic lion’s made
  • 100% from natural mushroom fruit bodies
  • Higher discounts on bulk orders
  • The Genius Brand Genius Mushrooms


    The Genius Brand’s Genius Mushrooms uses lion’s mane, cordyceps, and reishi mushrooms to support energy, stress relief, memory, and liver health, among other benefits.

    Genius Mushrooms is one of the best-known and most popular mushroom supplements available online today. Genius Mushrooms is popular for those who want to enjoy the benefits of mushrooms in an easy-to-take way.

    Ingredients Cordyceps, lion’s mane, and reishi
    Key highlights
  • Promotes liver functioning
  • Eliminates the feeling of fatigue and stiffness
  • Increases physical performance and energy level
  • Reduces stress and anxiety
  • Price $22
    Other Perks
  • 10% off on first order
  • Backed with more than 22000 positive reviews
  • 100% natural formula
  • Made in the United States
  • Mushroom Revival


    Mushroom Revival admits that they’re “obsessed with the power of mushrooms.” By buying a Mushroom Revival supplement today, you too can enjoy the benefits of mushrooms.

    Popular Mushroom Revival formulas include the Reishi Calm Tincture, the Mushroom Mix Daily 10 Tincture, the Lion’s Mane Focus Tincture, and the Cordyceps Energy Tincture. Whether looking for a specific mushroom blend or a collection of multiple mushroom extracts, Mushroom Revival has a range of formulas to help you enjoy the benefits of mushrooms in tincture form.

    Ingredients Chaga, cordyceps, Lion’s mane mushroom, Shiitake, maitake, and turkey tail capsules
    Key Highlights
  • Better immune function
  • Enhanced brain power
  • Increases energy levels
  • promotes digestive system
  • Price $35
    Other Perks
  • Proven organic mushrooms are added
  • There are no side effects
  • bonus on subscription orders
  • Tastes good
  • Earth Nutri Performance Energy + Focus


    Earth Nutri Performance’s Energy + Focus is a best mushroom supplement that aims to enhance your physical and mental energy using a blend of mushrooms and other ingredients. It’s like a nootropic and mushroom formula rolled into one.

    For mushrooms, Energy + Focus uses a blend of multiple mushrooms to improve your peak power, reduce exhaustion, and sustain higher activity levels for longer periods of time. Just mix one stick with water, then drink Energy + Focus daily for a high-powered burst of mushroom-based energy.

    Ingredients Citicoline, alpha-GPC, organic mushroom powder, theacrine, cordyceps, reishi, king trumpet, shiitake, lion’s mane, and turkey tail mushroom extracts
    Key Highlights
  • Increases energy levels
  • Boost motivation level and memory power
  • Improve alertness
  • Healthy mental performance
  • Price $40
    Other Perks
  • GMO and sugar-free formula
  • 15% discount on recurring order
  • Different flavors
  • Free shipping and early delivery
  • FreshCap


    FreshCap offers several mushroom supplements, mushroom coffees, and mushroom powders. You can get morning energy, nighttime relaxation, and other health benefits by taking daily FreshCap’s formulas.

    According to FreshCap, the company’s mushroom supplements can support health and immunity, focus and mental clarity, energy and stamina, and more. You can buy specific mushroom supplements like the Lion’s Mane Capsules and Turkey Tail Capsules ($35 apiece).

    If you want effective and best mushroom supplements packed into attractive and trendy packaging, then FreshCap is one of the better options available online today.

    Ingredients Organic Chaga extract, organic Cordyceps, organic Lion’s Mane, Organic Maitake, Organic Turkey Tail, and organic Reishi mushroom
    Key Highlights
  • Lowers blood pressure and blood sugar level
  • Prevent free radical damage
  • Mental health benefits
  • Increases energy and stamina
  • Price $35+
    Other Perks
  • High quality and organic mushrooms
  • 60 days money-back guarantee
  • Earliest delivery within the United States
  • Manufactured under FDA practices
  • VidaCap


    VidaCap is the best mushroom supplement company that offers a range of supplements targeting specific goals (like ‘Sleep’) or specific mushrooms (like ‘Reishi’ and ‘Lion’s Mane’ supplements). VidaCap’s supplements allow you to enjoy the effects of mushroom supplements at a reasonable price without compromising on quality.

    Each VidaCap supplement contains premium-grade mushrooms sourced from closed greenhouses in China and Russia. The mushrooms are sun-dried, screened, and milled after harvesting.

    IngredientsReishi, passionflower and melatonin, turkey tail, lion’s mane, cordyceps and Chaga
    Key highlights
  • Better sleep quality
  • Boost energy and physical performance
  • Turkey Tail capsules for the stronger immune system
  • Reduces stress and cognitive decline
  • Price$24
    Other perks
  • Backed with five-star ratings
  • Premium grade mushroom complex
  • Expertly processed formulas
  • Clear labeling of ingredients
  • Shroomy


    Shroomy is one of only two medicinal mushroom supplements on this list that comes in the form of a gummy. Shroomy gummies are marketed as nootropic mushroom blends to support cognition in various ways.

    According to Shroomy, the lion’s mane mushroom in their gummies will act as a proven cognition booster, giving you greater mental clarity while working or studying. Reishi, meanwhile, boosts your immune system while cordyceps enhance energy levels by optimizing ATP production.

    If you want to enjoy the benefits of mushroom supplements with the convenience of a gummy, then Shroomy may be the best option for you.

    Ingredients Reisha, Cordyceps mushrooms, and Lions Mane mushroom extracts
    Key Highlights
  • Supports cognitive health
  • Enhances mental energy
  • Boost energy level and physical performance
  • Strengthen your immune system
  • Price $30
    Other Perks
  • 100% plant-based
  • Discount on subscribe and save orders
  • Best way to consume mushroom extracts
  • Gluten-free best known medicinal mushroom formula
  • Ceremony Mushrooms


    Ceremony Mushrooms offers several mushroom-based wellness blends. The company is best-known for its mushroom tinctures. Ceremony Mushrooms offers mushroom tinctures with targeted benefits, including the Stress Relief Tincture, Sleep Tincture, Mushroom Blend Tincture, and Digestion Tincture. Each tincture contains a potent combination of mushrooms, adaptogens, herbs, and other plant-based ingredients.

    Ingredients All medicinal mushroom extracts
    Key Highlights
  • Every tincture offers better sleep quality
  • Elevates mood patterns
  • Improves immunity
  • Boost brain health
  • Price $45+
    Other Perks
  • 100% plant-based ingredients
  • Sugar-free medicinal mushroom formulas
  • Manufactured under FDA approved centers
  • Free shipping above $150
  • Gundry MD Mushroom Vitality


    California-based anti-aging supplement company GundryMD has launched a mushroom supplement called Mushroom Vitality. With top ratings and a high price tag, Mushroom Vitality can support healthy immune function while giving you more energy in the morning.

    Mushroom Vitality is one of the few mushroom supplements on this list that comes in the form of a liquid tincture: you squeeze 4mL (approximately five droppers) into a glass of water, then drink Mushroom Vitality daily.

    The formula was developed by a physician (Dr. Gundry), giving Mushroom Vitality added legitimacy over competing mushroom supplements listed here.

    Ingredients Reishi mushroom fruiting body, Chaga mushroom mycelia, and Coriolus mushroom fruiting body with mycelia
    Key Highlights
  • It keeps you energetic and active
  • Supports healthy immune function
  • It makes you feel healthy and strong
  • Protects your body from bacterial and viral infections
  • Price $66
    Other Perks
  • Manufactured in the USA
  • 90 days money-back guarantee
  • No artificial sweeteners are added
  • Made under GMP facilities
  • Circadian Wellness


    Circadian Wellness uses its proprietary “Quicksome” technology to make high-quality mushroom-based formulas targeting specific benefits. Today, you can buy Circadian Wellness mushroom supplements targeting sleep, energy, pain, cognition, and libido, among other effects.

    Circadian Wellness was founded with the assumption that re-aligning your circadian rhythm is crucial for a healthy mind, body, and soul. Taking the right supplements daily can restore your circadian rhythm and support optimal health. And, because of Circadian Wellness’s Quicksome technology, you can enjoy more excellent absorption with lower doses of mushroom.

    Ingredients Lion mane’s, cordyceps, and reishi mushroom extracts
    Key Highlights
  • Reduces body pain and aches
  • It eliminates, the chances of stress and anxiety
  • Targets better sleeping patterns
  • Enhances libido and testosterone level
  • Price $30+
    Other Perks
  • Uses quick some technology
  • Satisfaction guaranteed
  • Discount on bulk orders
  • Made in the USA
  • VitaPost Immune Support


    Immune Support is an immune-boosting supplement from VitaPost. The supplement contains a blend of plant-based extracts to support your immune system in various ways, including mushroom extract.

    With VitaPost Immune Support, you can give your body the mushroom extracts and other ingredients you need to support your immune system in various ways. At just $14 per bottle, Immune Support is also one of the most reasonably-priced mushroom supplements on this list.

    Ingredients Vitamin E, Green tea, Beta Glucans Graviola Leaf, Shiitake, maitake and reishi mushroom extracts
    Key Highlights
  • Supports immunity
  • Nourish your body
  • Increases physical performance
  • Improves metabolic rate
  • Price $14
    Other Perks
  • No side effects
  • 100% natural formula
  • Laboratory tested formula
  • Sourced from GMP Certified facility
  • MycoPhyto Complex


    MycoPhyto Complex is a mushroom supplement that combines six proven mushroom extracts into one convenient capsulated formula. The company has also added an extra dose of 50mg of beta-glucan to optimize the health-supporting benefits.

    Advanced Bionutritionals make MycoPhyto Complex. Formulated by medical doctor Dr. Isaac Eliaz, MD, MycoPhyto Complex combines more potent six medicinal mushrooms backed by studies proving they support health in various ways.

    Ingredients Reishi, cordyceps, turkey tail, Polyporus, royal Agaricus, and maitake mushroom extracts
    Key Highlights
  • Supports occasional cold and flu
  • Keeps your healthy and balanced immune system
  • Enhanced energy and stamina
  • Promotes cardiovascular and respiratory system
  • Price $40
    Other Perks
  • Backed with 100s positive reviews
  • 100% Natural formula
  • Made under GMP facilities
  • Recommended by doctor
  • Brain Forza Organic Lion’s Mane Mushroom


    Brain Forza’s Organic Lion’s Mane Mushroom supplement uses USDA Organic certified lion’s mane mushrooms that are lab-grown, making them significantly stronger than wild-grown mushrooms. The mushrooms are cooked twice to 125 degrees Celsius.

    Brain Forza markets its Organic Lion’s Mane Mushroom formula as a way to optimize brain health, memory, neuroprotection, and healthy mood, among other effects. The formula is two to six times stronger than other major lion’s mane mushroom extracts because it contains over 1g of polysaccharides per serving.

    Ingredients Lion mane’s, reishi, turkey tail, and cordyceps mushrooms
    Key Highlights
  • Enhances memory and focus
  • Promotes mental and brain health
  • Supports immune function
  • Increases energy level
  • Price $40
    Other Perks
  • USDA certified organic ingredients
  • The formula is free from heavy metals and pesticides
  • Gluten free and Non GMO product
  • Made in the USA
  • Goldmine Supershroom Powder


    Goldmine Supershroom Powder is one of the most recognizable names in the mushroom supplement space today. Goldmine Supershroom Powder protects and strengthens your immune system using antioxidant-rich, anti-inflammatory mushrooms and herbs.

    Take 0.5 to 1 teaspoon of Goldmine Supershroom Powder up to three times per day to enjoy tasty plant magic while supporting health benefits.

    Ingredients Lucuma, ginger, astragalus, reishi fruiting body mushroom, turkey tail fruiting body mushroom, and maitake fruiting body mushroom
    Key Highlights
  • Protects your immune system from viral infections
  • It offers various health benefits like lower blood pressure
  • Boost memory and focus
  • Promotes digestive and gut health
  • Price $28
    Other Perks
  • USDA certified ingredients
  • Unflavoured mushroom supplement
  • Sign up and save 10%
  • 90 days return policy
  • Magic Mushroom

    image sells a Magic Mushroom powder. Understandably, the formula does not technically contain ‘magic’ mushrooms; instead, it’s a blend of mushroom powders with magical benefits. tests all supplements in a third-party lab before, during, and after production to ensure they’re of the highest quality. The company recommends using Magic Mushroom powder in recipes, drinks, oatmeal, shakes, and other foods and beverages of your choice. It’s like hot chocolate powder with benefits, giving you the tastiness of a hot chocolate powder mixed with proven mushroom extracts.

    Ingredients Cacao, Chaga, ashwagandha, reishi, lucuma, and cinnamon.
    Key Highlights
  • It calms and relaxes the mind
  • Supports healthy natural defense system
  • Improve overall health and wellbeing
  • Strengthen digestive system
  • Price $35
    Other Perks
  • No artificial sweeteners or gums are added
  • Contains ayurvedic herbs
  • Savings on large orders
  • USDA Organic certified ingredients
  • Spore


    Spore is a mushroom supplement that enhances daily cognitive function, eliminates brain fog for improved clarity, boosts mental energy and focus, and supports creativity, among other benefits.

    Spore contains a blend of proven mushrooms with popular adaptogens, supporting health in multiple ways, like other mushroom supplements listed here. According to the manufacturer, Spore works as a natural energy booster, libido booster, neuroprotective supplement, and anti-aging formula while also providing daily cognitive support.

    Ingredients cordyceps, ashwagandha, Ginkgo Biloba, and lion’s mane mushrooms
    Key Highlights
  • Significant testosterone and libido booster
  • Boost energy level
  • Protects neurotransmitters from age-related decline
  • Increases memory power and focus
  • Price $50
    Other Perks
  • 30 days money-back guarantee
  • USDA organic certified formula
  • Made in the United States
  • Vegan-friendly supplement
  • Vital Plan Adaptogen Recovery


    Vital Plant’s Adaptogen Recovery is an immune support formula created by Dr. Bill Rawls. Dr. Rawls developed the adaptogenic herbal formula to strengthen immune health and make your body more resilient.

    The mushroom extracts present in the supplement are believed to have powerful immune system effects by acting as adaptogens, which means they help your body respond to physical and cognitive stress. Vital Plan’s Adaptogen Recovery is one of the best mushroom supplements available today – especially for those looking for immune-boosting benefits.

    Ingredients Chinese skullcap extract, cordyceps extract, reishi mushroom extract, and Remannia extract
    Key Highlights
  • Boost immunity to fight against viral infections
  • Enhances cognitive health
  • Reduces stress and anxiety-related issues
  • Promotes mental performance
  • Price $72
    Other Perks
  • 90 days money-back guarantee
  • Keto-friendly formula
  • 100% natural supplement
  • Non-GMO product
  • The Drug Store Adaptogenic Mushrooms


    TheDrug Store offers over a dozen adaptogenic and medicinal mushrooms targeting different health and wellness goals. Popular medicinal mushroom supplements include Wunder Workshop, Glow Bar, and Anatomy. Some supplements are designed to target immunity. Others are designed for cognition or overall health and wellness.

    TheDrug.Store is a London, UK-based supplement company offering an extensive range of supplements, including CBD oils to nootropics to mushroom blends. Whether looking for mushroom tinctures, medicinal mushroom powders, or other mushroom supplements, TheDrug.Store has a surprisingly extensive range of options at a competitive price.

    Ingredients Four types of mushroom extracts, omega 3 fatty acids, Vitamin D and Vitamin B12
    Key Highlights
  • Promotes overall health and wellbeing
  • Supports digestive and gut health
  • Alleviates age-related diseases
  • Boost physical performance
  • Price $20+
    Other Perks
  • 10% discount on first order
  • Guaranteed money back policy
  • 100% natural formula
  • Made under GMP practices
  • Botany Cordyceps Militaris Extract


    Botany is a supplement company offering a popular mushroom formula called Cordyceps Militaris Extract. With 30g of cordyceps extract per jar and 1% cordycepin concentration, Botany’s mushroom supplement gives you all of the benefits of cordyceps in a convenient way.

    The PET single-wall jar ensures your cordyceps arrive at your address ready to provide all the powerful benefits you would expect. Each jar is UV-resistant to minimize degradation. Botany partners with a third-party lab to verify the purity of all formulas, and the company publishes its lab test results online. For a high-quality cordyceps supplement you can trust, Botany’s Cordyceps Militaris Extract may be the right choice for you.

    Ingredients Cordyceps extract and 1% cordycepin concentration
    Key Highlights
  • Better immunity
  • Enhanced sleep and mood pattern
  • Promotes digestive health
  • Brings mental balance
  • Price $24
    Other Perks
  • High Purity and addictive free formula
  • Affordable mushroom supplement
  • Lab certified mushroom extracts
  • Free and same-day shipping
  • Plant People WonderDay


    Plant People’s WonderDay is the second mushroom gummy on this list. While most other gummy supplements come in the form of a powder, capsule, or tincture, WonderDay delivers the same benefits in gummy form.

    Whether looking to support stress, energy, performance, digestion, or your immune system, you may be able to find the benefits you’re looking for – in a convenient way – with WonderDay mushroom gummies. The gummies have a wild raspberry flavor that tastes surprisingly good. According to Plant People, the WonderDay mushroom gummies can support the stress response, energy, mood, and immunity, among other benefits.

    Ingredients Lion’s mane, Shiitake, maitake, chaga, and reishi mushroom extracts
    Key Highlights
  • Keeps you energetic and active
  • Boost digestive system and gut health
  • Enhances immunity
  • Reduces stress level
  • Price $30
    Other Perks
  • No dyes or corn syrup added
  • Lab-tested formula
  • Vegan and keto-friendly Supplement
  • Made under FDA approved facilities
  • 5 Mushrooms Reserve Blend


    5 Mushrooms Reserve Blend is a mushroom supplement that contains varieties of ten functional mushrooms that aims to provide multiple benefits using multiple mushrooms. Some of the ingredients in 5 Mushrooms Reserve Blend target immunity. Others target cognition and brain health.

    5 Mushrooms Reserve blend makers describe their formulas as the “world’s grooviest mushroom supplement.” You get four dietary supplements in one, including an immune, mood, nootropic, and energy supplement.

    Ingredients Reishi, lion’s mane, cordyceps, turkey tail, and Chaga mushroom extracts
    Key Highlights
  • Works as a cognitive enhancer
  • Optimizes brain health
  • Supports memory and focus
  • Energy booster
  • Price $30
    Other Perks
  • Free drops and relief on pre-order
  • 10% discount on the purchase of 3 packs
  • Free shipping
  • Natural formula
  • MindHoney


    MindHoney is a nootropic supplement made by Dose Nomadic Nutrition. The manufacturer believes MindHoney can support cognition, memory, focus, alertness, and mood. The formula contains powerful ingredients to enhance energy production and focus, balance mood and stress, boost immunity and mental wellness and improve brain function and memory, among other effects.

    Key ingredients in MindHoney include lion’s mane, cordyceps, reishi, and Chaga mushroom extracts, four of the most popular and proven mushroom extracts available today. Just take two capsules daily to support cognition in multiple ways.

    Ingredients Neurofactor, Coffeeberry, NALT, DMAE, L-theanine, ashwagandha, and ginseng and essential mushroom extracts
    Key Highlights
  • Promotes overall health and well being
  • Increases memory power and focus alertness
  • Prevent free radical damage
  • Aids in weight loss
  • Price $32
    Other Perks
  • No snake oil or harmful chemicals are added
  • Free domestic shipping
  • 100% organic and vegan product
  • Made in the USA
  • Vital Plan Brain Boost


    Brain Boost is the second Vital Plan supplement on this list. Brain Boost uses a similar blend of mushroom extracts to Adaptogen Recovery, giving your body the mushrooms it needs to support memory, cognition, clarity, focus, energy, mood, and immunity, among other effects.

    Although Adaptogen Recovery and Brain Boost both use mushrooms, the two formulas contain different types of mushrooms to provide different targeted effects. If you want to support brain health more than you want to support immunity, then Vital Plan’s Brain Boost may be the right choice.

    Ingredients Lion’s mane, cat’s claw, Bacopa Monnier, ashwagandha, and ginkgo Biloba
    Key Highlights
  • Boost immunity
  • Enhances cognitive health
  • Boost metabolic rate
  • Ensures better gut health
  • Price $48
    Other Perks
  • Physician formulated blend
  • Free US shipping
  • Discount on subscription orders
  • Natural formula
  • How We Ranked

    All medicinal mushroom companies make similar promises about their benefits and effects. However, only the top-ranked mushroom supplement companies live up to these promises.

    Here’s how we separated the best and worst medicinal mushroom supplements available today:

    Proven Ingredients: There are thousands of mushrooms and fungi in the world today. Only a handful are used in mushroom supplements. We preferred mushroom supplements that used proven ingredients linked to various benefits in scientific studies.

    Clinically Effective Dosages: Some mushroom supplements contain the right ingredients at the wrong dosages. Some supplements have too few active ingredients to achieve any real benefits. Other supplements hide low dosages behind proprietary labels, making it difficult to see individual ingredient breakdowns. We preferred mushroom supplements with strong, clinically effective dosages.

    Backed by Trials or Tests: Most mushroom supplement companies do not invest in their own clinical trials. However, some companies, including Onnit, have invested in clinical trials proving their formula works. The more scientific research a mushroom supplement company provided, the higher it was ranked.

    Manufacturer Reputation & Transparency: Some mushroom supplement companies are completely transparent with their ingredients, dosages, testing, ingredient sources, and manufacturing processes. Others are worryingly vague. We preferred manufacturers with a strong reputation for transparency and quality.

    Production Methods (Whole Fruiting Body Versus Other Methods): Mushroom supplement companies produce supplements differently. Some companies use the whole fruiting body, using all of the mushrooms for their beneficial effects. Other companies use myceliated grain production methods (using the mushroom’s roots). Some companies also use ‘full spectrum’ and ‘pure mycelium,’ creating mushroom supplements with full effects.

    Extraction Methods: There are multiple medicinal mushroom extraction methods. In traditional use, people have used hot water extraction. Today, some supplement companies use alcohol extraction or dual extraction to maximize the concentration of active ingredients in the finished product. The type of extraction also varies by mushroom: softer mushrooms like lion’s mane are ideal for hot water extraction, while harder mushrooms like reishi are not.

    Medical Advisory Board: Some mushroom supplement companies have a medical advisory board. Some companies are even led by real medical doctors, giving them an added degree of legitimacy over other mushroom supplement companies. We preferred mushroom supplements that had been verified, tested, or approved by some type of certified specialist – like a medical doctor.

    Advertised Benefits: Medicinal mushrooms could have revolutionary potential. However, some mushroom supplement companies go overboard with their advertised benefits, suggesting their formulas can cure or prevent diseases. We preferred mushroom supplement companies with honest and transparent advertised benefits.

    Moneyback Guarantee: Even the best mushroom supplements won’t work for everyone. That’s why we prefer mushroom supplements backed by a money-back guarantee. Good mushroom supplement companies back their claims with a guarantee, making it easy to request a refund if you’re unsatisfied with the results.

    Scientific Evidence for Medicinal Mushrooms and Mushroom Supplements

    Scientists believe there are over 1.5 million species of fungi on the planet. Approximately 25% of the planet’s biomass is believed to consist of fungi.

    Only a tiny fraction of these species are believed to have medicinal benefits. However, researchers continue to perform trials on fungi to verify and test these benefits.

    Cordyceps is one of the best-known mushrooms in the supplement space today. It’s prized for its effects on athletic performance, stamina, lung function, and even sexual function. Used in traditional Chinese and Tibetan medicine for centuries, cordyceps grow naturally in the high altitudes of Tibet. In this 2010 study on cordyceps, researchers found that the mushroom extract improved exercise performance in elderly subjects. Researchers gave 20 healthy elderly patients (50 to 75 years old) 333mg of cordyceps or a placebo three times a day for 12 weeks. After 12 weeks, researchers observed improved endurance, exercise performance, and metabolic energy in the cordyceps group.

    Reishi is another popular mushroom that traces its history to traditional Chinese medicine. There’s some evidence that reishi impacts immunity, energy, cognition, anxiety, and sleep, among other effects. The mushroom grows naturally in hardwood trees and stumps. In this 2018 study, researchers reviewed the evidence on reishi mushrooms, finding that active ingredients had anti-tumor, antioxidant, and immune-modulating properties, among other benefits. Researchers also found that the reishi mushrooms had a calming effect.

    Some people use mushrooms to help with allergies. Yes, taking a mushroom extract could reduce allergy symptoms. According to this study, reishi mushroom extract can replicate the effects of allergy medications. Some people can even stop taking over-the-counter antihistamine allergy products after taking a reishi mushroom supplement.

    Many mushroom supplements contain maitake mushroom extract. Maitake supports the immune system, targets digestive problems, and regulates blood sugar, among other benefits. Researchers believe maitake mushroom extract works because it’s a rich source of beta-glucans, polysaccharides that help control blood sugar, inflammation, weight, and more. Researchers found that the beta-glucans in maitake mushrooms could help with cholesterol, blood pressure, and weight loss in this study. Other studies have found that maitake mushroom extract could support the immune system during chemotherapy.

    Shiitake is a well-known mushroom used in gourmet recipes – but also with growing evidence as a medicinal mushroom. Shiitake is the second most common mushroom globally (behind only the ordinary button mushroom), and it’s trendy in Asian cuisine. Studies have linked shiitake mushroom extract to radiant skin, liver health, cholesterol, and more. Researchers in Japan even created a highly purified type of shiitake mushroom extract licensed to treat gastric cancer. Meanwhile, this study showed that shiitake mushrooms could play a role in reducing cholesterol.

    Turkey’s tail, also known by its scientific name of Coriolus Versicolor, is a colorful mushroom extract that is not used in cooking because of its tough texture and bitter taste. However, the turkey tail mushroom is prized for its benefits. Research shows that turkey tail mushroom extract contains two plant-based compounds (polysaccharides) linked to immunity, including PSK (Krestin) and PSP (polysaccharide peptide). In this study, the turkey tail was shown to support the immune system when dealing with cancer treatment. This second study showed that turkey tail extract improved outcomes for cancer patients by supporting immune cell production.

    Chaga mushroom extract may be the most unpleasant looking mushroom on this list, but it’s also one of the richest fungi-based sources of antioxidants. Antioxidants control inflammation throughout your body, neutralizing the effects of free radicals. According to one study, the antioxidants in chaga mushroom extract also seem to help with digestive disorders. Another study found that the antioxidants had antiviral effects, killing viruses and bacteria within the body to support immunity.

    Many of the top-rated mushroom supplements available today contain lion’s mane mushroom extract. Like Chaga, the lion’s mane mushroom has a unique and bizarre appearance, unlike the traditional mushrooms we know. Studies show that the lion’s mane also has unique properties. One study found that lion’s mane stimulated the production of nerve growth factor (NGF), which influences brain neurons while also impacting immunity. Another study showed that patients reported improved wellbeing after taking 2g of lion’s mane mushroom extract per day.

    In one clinical trial, Onnit’s Shroom Tech SPORT was shown to lead to significant benefits in endurance, energy, and more. Researchers found that Shroom Tech SPORT led to a 12% increase in bench press reps, a 7% increase in back squat reps, and an 8.8% improvement in cardio performance, among other benefits. While most mushroom supplement companies do not invest in clinical trials, Onnit has invested in clinical trials proving the formula works as advertised. Shroom Tech SPORT mostly consists of cordyceps.

    As more research gets released, we’re learning more about the science-backed benefits of medicinal mushrooms and today’s top mushroom supplements.

    FAQs About Medicinal Mushrooms and Mushroom Supplements

    Whether dealing with medicinal mushrooms or mushroom supplements, we get plenty of questions about why the top-rated products are the best mushroom supplements to use. Here are some of the most frequently asked questions we receive.

    Q: How do mushroom supplements work?

    A: Mushroom supplements are rich in natural, plant-based ingredients like beta-glucans, sterols, and terpenoids. These ingredients have been linked to various benefits in multiple studies. Each mushroom also has hundreds of unique natural chemicals, antioxidants, and phytochemicals believed to support various benefits.

    Q: How do I take mushroom supplements?

    A: You can take mushroom supplements as a powder, capsule, or tincture. Some mushroom supplements even consist of whole, fresh mushrooms. Generally, you take mushroom supplements as a capsule, although you can also take a tincture sublingually (apply drops underneath the tongue) or by mixing a powder with water or a shake. You can even find mushroom gummy supplements.

    Q: Are mushroom supplements legal?

    A: Mushroom supplements are legal when they contain ingredients that are generally recognized as safe (GRAS) by the FDA. Psychedelic and medicinal mushrooms are controlled substances, but mushrooms like lion’s mane and turkey tail mushrooms are GRAS and legally available as supplements.

    Q: Can I buy medicinal mushroom supplements?

    A: ‘Medicinal mushrooms’ is a general term for mushrooms that are believed to have health benefits. Some supplement companies market their mushroom supplements as medicinal mushroom products. However, medicinal mushrooms with psychoactive ingredients (like psilocybin) are controlled substances and illegal in supplement form.

    Q: What are the side effects of mushroom supplements?

    A: Mushrooms are generally recognized as safe, which means they should not cause serious side effects in healthy people when used in normal doses. However, some are allergic to mushrooms and their active ingredients. Others experience mild digestive discomfort and other effects.

    Q: What are medicinal mushrooms?

    A: Medicinal mushrooms are fungi species packed with antioxidants.

    Q: What are magic mushrooms?

    A: Magic mushrooms are mushrooms with psychedelic properties. They’re not legally available in supplement form, and they contain psilocybin and other psychoactive components.

    Q: What is psilocybin?

    A: Psilocybin is a psychoactive ingredient found in certain types of mushrooms.

    Q: Is psilocybin legal?

    A: Psilocybin is illegal and has been classified as a Schedule I illicit drug in the United States since 1970. As a Schedule I drug, psilocybin has no currently accepted medical use in the United States. However, there’s a growing push to legalize psilocybin for medicinal purposes.

    Q: How does psilocybin work?

    A: Researchers don’t know how psilocybin works. We know it triggers psychedelic effects in the brain, including hallucinations. Some studies show that psychedelic drugs prompt the growth of new neurons and branch between dendrites, changing brain communication. However, we need more research to determine how psilocybin and magic mushrooms work.

    Q: Are mushrooms addictive?

    A: Mushroom supplements are not addictive. They do not contain habit-forming ingredients. Even psilocybin and magic mushrooms are considered to only have mild addiction potential because they don’t activate the same reward center of the brain as other drugs.

    Q: Are mushrooms a fruit or vegetable?

    A: Mushrooms are classified as fungi, which means they’re neither fruits nor vegetables.

    Q: Where do mushrooms come from?

    A: Most mushroom supplement companies source their mushrooms from China and India. However, you can find some mushroom ingredients grown in the United States, particularly maitake and shiitake mushrooms

    Q: Where do mushrooms grow in the United States?

    A: Mushrooms grow all over the United States. However, approximately 60% of the country’s mushroom production comes from Pennsylvania.

    Q: What are the health benefits of mushrooms?

    A: Many people take mushroom supplements for immunity, detoxification, general health and wellness, and other effects.

    Final Word

    Mushroom supplements are more popular than ever. Today, you can buy mushroom powders, capsules, tinctures, and gummies, making it easy to get your daily dose of mushrooms in any form.

    When reviewing the best medicinal mushroom supplements, whether in pill, powder or drink form, there is no denying these are the top rated mushroom products to buy in 2021.

    To learn more about mushrooms, or to buy the best mushroom supplements and medicinal mushroom products available today, check our list of the best mushroom supplements above.

    RELATED:Best Immunity Boosters – Top Immune System Supplements That Work

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