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Best Nootropics: Top Nootropic Supplements to Boost Brain Health

Many people take nootropic supplements for memory, cognition, and overall brain health.

The right nootropic supplement can boost memory, enhance focus, and make you feel smarter.

Some natural nootropics work by supporting blood flow to the brain. Others work using synergistic blends of plants, herbal extracts, vitamins, and minerals.

Whether you’re an older adult, a college student, a worker in a competitive environment, an entrepreneur, an athlete, or anyone looking for an edge, nootropic supplements are more popular than ever.

With so many nootropics available, it’s challenging to pick the right one for you. We want to help. Here are the best nootropic supplements available in 2021.

Ranking the Top 33 Nootropic Brain Booster Supplements

Every nootropic supplement claims to boost brainpower. Some of them work, while others do not. Here are the best science-backed nootropic supplements available today.

SANE Vitaae: A “Brain Trick” to improve memory by 90%
Mind Lab Pro: Mind Lab Pro is proven by independent research
Nuzena Neuro Focus +:A formula for optimal brain function
NooBru: Maximize your brain potential
Nootrogen: Natural nootropic brain support
Ageless Brain: A blend of 11 best ingredients for brain health
Onnit Alpha Brain: A daily cognitive support with carefully selected ingredients
Hunter Focus: This premium supplement gives you faster results for focus support
Qualia Mind: The most advanced formula for mental support
Performance Lab Mind: Performance Lab Mind is an ultramodern nootropic supplement for brain focus
Vital Plan Brain Boost: It is formulated by physicians to target poor cognitive health
NaturalCell NeuroActiv6: Advance brain support formula for faster results
Synapse XT: A natural way to healthy brain and hearing function
NooCube: Contain wholesome ingredients for improving brain productivity
Natural Stacks NeuroFuel: An original CILTEP® formula that works within 30 minutes of your first dose
UpWellness Mind & Mood: #1 proven way to lower stress and anxiety
PureEssence BrainEssence: Contains world’s most profound nootropic nutrients
PureHealth Research Ageless Brain: A premium nootropic brain supplement
Brain C-13:A doctor-formulated solution made with herbs
Cymbiotika Golden Mind: A formula with advanced brain nutrients
Elm & Rye Nootropics: This proprietary blend can help boost cognitive function
CogniBiotics: CogniBiotics is an advanced formula with probiotics for better brain and gut health
Amy Myers MD NeuroLive:Physician formulated solution with seven brain-supporting micronutrients
Neuro:These functional gums boost your brain functioning quite easily
OptiMind: Made with premium ingredients, this nootropic blend is perfect for enhancing focus and energy
Youthful Brain: Made by NASA Doctor Sam Walters for ensuring youthful brains
Oweli Neuro:Neuro will unleash your brain potential by 100%
ReMind Solution:This advanced cognitive enhancer supports six different indicators of mental performance
Brain Pill:Brain Pill is a best secrete weapon for peak mental performance
ProMind Complex:A unique formula for healthy brain health
Memory Hack: This claims to improve brain cells and memory overnight and instantly
MemoSurge: An extremely powerful supplement for improving brain function
Memo Defend: Called ‘A Work Of Art,’ Memo Defend is a pure and effective solution for optimum brain functioning

SANE Vitaae

Product Description
Ingredients:SANE Vitaae includes folate, vitamin D, acetyl L-carnitine, omega-3 fatty acids, citicoline, CoQ10, and more
Key Benefits:
  • Improve mental clarity and cognitive functions
  • Lets you enjoy the deeper concentration
  • Improve your mood and nervous system
  • Quantity:45 capsules
    Dosage:3 capsules per serving
    Assurance:One-year refund guarantee
    SANE Vitaae Price: $47

    Vitaae from SANE Laboratories is a leading nootropic formula. While other natural nootropics use herbal extracts and vitamins, Vitaae uses antioxidants like CoQ10 to target inflammation in your brain. According to SANE Laboratories, the formula could lead to a 13.6% increase in brain energy utilization and a 26% increase in membrane turnover, among other unique benefits.

    Mind Lab Pro

    Product Description
    Ingredients:Key ingredients in the Mind Lab Pro blend include citicoline, Maritime pine bark extract, Bacopa monnieri, lion’s mane mushroom, and Rhodiola Rosea extract, among others
    Key Benefits:
  • Mind Lab Pro will Improve mental acuity
  • Promote healthy brain cells and mental benefits
  • Improve brain function for a long time
  • Quantity:60 capsules
    Dosage:Take two capsules of Mind Lab Pro daily
    Assurance:Empty bottle money-back guarantee
    Mind Lab Pro Price: $69

    Mind Lab Pro is the internet’s best-known and best-rated nootropic stack. Although it’s more expensive than competing options, Mind Lab Pro is an ideal introductory nootropic for those looking to get started in the space.

    Every serving of Mind Lab Pro contains 11 research-backed brain boosters. With substantial dosages, third-party testing, and no pointless ingredients, Mind Lab Pro is one of the internet’s best-rated nootropic formulas for a reason.

    Mind Lab Pro comes from Opti-Nutra, a supplement company with a medical advisory board. That board is led by neuroscientists like Dr. Ramon Velazquez, Ph.D.

    Nuzena Neuro Focus +

    Product Description
    Ingredients:You get 692mg of a proprietary blend with DMAE bitartrate, green tea extract, bilberry fruit extract, amino acids, Maritime pine bark extract, and other active ingredients
    Key Benefits:
  • Boost mental performance
  • Improve cognitive function
  • Enhance focus and mental energy
  • Quantity:60 capsules
    Dosage:Take two capsules daily
    Nuzena Neuro Focus + Price: $30 (or $60 for 3 bottles)

    Nuzena’s Neuro Focus + is a nutritional nootropic stack that supports memory recall, mental focus, and cognitive function. Made in the United States, Neuro Focus +is priced at around $60 per bottle, although you must buy a minimum of three bottles per purchase, making Neuro Focus + the only supplement on the list with this type of offer. If you want one of the best-value nootropic supplements available today, then Neuro Focus + may be the right choice for you.


    Product Description
    Ingredients:NooBru is a powder containing alpha GPC, vitamin B5, L-theanine, ashwagandha, choline bitartrate, Huperzine A, and other proven ingredients
    Key Benefits:
  • Promote better brain function
  • Boost mental energy and focus
  • Help at brain cell regeneration
  • Quantity:20 servings
    Dosage:Just mix either powder with water or the beverage of your choice, then drink it daily
    Assurance:100% risk-free guarantee
    NooBru Price: $55

    Launched in 2020, NooBru has made a splash in the nootropic supplement space for its tasty flavor, 13 active ingredients, and extensive media attention. The formula is marketed to athletes, older adults, students, and competitive workers,

    One of the best things about NooBru is its transparency. While other nootropic supplements hide active ingredients within proprietary formulas, NooBru discloses all ingredients and dosages upfront. Y


    Product Description
    Ingredients:The supplement contains ingredients we don’t see with different formulas, including glutamic acid, L-tyrosine, amino acids, and DMAE
    Key Benefits:
  • Support energy, focus, and stress by targeting brain pathways
  • Optimize brain cells and brain chemicals
  • Boost your cognitive abilities
  • Quantity:60 capsules
    Dosage:Take two capsules every day
    Nootrogen Price: $30

    Nootrogen makes many of the same promises seen with other nootropic stacks listed here. One of the most significant advantages of Nootrogen is the price. Nootrogen is surprisingly affordable compared to competing options listed here. Although dosage is average, the price-to-value ratio makes the Nootrogen nootropics stack a much more attractive option.

    Ageless Brain

    Product Description
    Ingredients:The formula contains natural ingredients like Bacopa monnieri, cat’s claw, guayusa, Camu Camu, dragon’s blood, cacao, and cinnamon, among others
    Key Benefits:
  • Avoid cognitive decline and poor mental function
  • Boost brain function with new brain cells
  • Improve mental processing speed
  • Quantity:60 capsules
    Dosage:Take two capsules every day
    Assurance:One-year satisfaction guarantee
    Ageless Brain Price: $55

    Ageless Brain from Organixx is a nutritional supplement for various cognitive benefits. If you’ve grown tired of other nootropic supplements and want to try something more unique, then Ageless Brain may be the right choice for you. Although more research is needed to verify the effects of some of these ingredients, the nootropic stack can support cognition in multiple ways using unique active ingredients.

    Onnit Alpha Brain

    Product Description
    Ingredients:Each serving of Alpha Brain contains natural nootropic ingredients like Bacopa monnieri, cat’s claw, oat straw, Huperzia Serrata, and other botanical amino acids
    Key Benefits:
  • Optimize brain health and memory retention power
  • Boost mental performance
  • Helps to maintain a better cognitive function
  • Quantity:90 capsules
    Dosage:Take three capsules daily
    Assurance:Risk-free money-back guarantee
    Onnit Alpha Brain Price: $35

    Onnit Alpha Brain is arguably the best-known nootropic supplement sold online today. Promoted by Onnit co-owner Joe Rogan, Alpha Brain supports memory, focus, and daily cognition.

    This nootropic stack is one of the few natural nootropics on this list, backed by peer-reviewed research and clinical trials. Most supplement companies do not invest in clinical trials because of the high cost. With Onnit Alpha Brain, you get a high-quality formula to give you the edge over the competition.

    Hunter Focus

    Product Description
    Ingredients:Key ingredients in Hunter Focus include Bacopa monnieri, Maritime pine bark extract, and phosphatidylserine, all of which can be found in other nootropic supplements listed here
    Key Benefits:
  • Enhances memory and focus
  • Promotes positive mood and creativity
  • Boosts brain energy levels
  • Quantity:120 capsules
    Dosage:Take four capsules daily
    Hunter Focus Price: $60

    Hunter Focus from Roar Ambition is a nootropic supplement that claims to give you an edge over the competition – whoever that competition may be. Each serving of Hunter Focus provides clear thinking with all-natural ingredients and a high-quality formula.

    Advertised as the smart solution to mental fatigue, Hunter Focus also has some of the most attractive packaging on this list. Hunter Focus has some of the highest dosages on our list, which is why it continues to be one of the internet’s top-rated nootropic supplements.

    Qualia Mind

    Product Description
    Ingredients:Artichoke leaf extract, Acetyl-L-Carnitine, DL-Phenylalanine, Taurine, Citicoline, Mucuna pruriens, Phosphatidylserine, and Theobromine
    Key Benefits:
  • Restore your brain chemicals
  • Reduce the symptoms of cognitive decline
  • Boost mental performance and focus
  • Quantity:154 capsules
    Dosage:Take two capsules daily
    Assurance:100 days money-back guarantee
    Qualia Mind Price: $59

    Qualia Mind from Neurohacker Collective is another popular nootropic supplement that backs up the hype with powerful active effects. Another advantage of Qualia Mind is the customization options: Neurohacker Collective offers four nootropic supplements under the Qualia brand, including Qualia Mind, Qualia Mind Caffeine Free, Qualia Mind Essentials, and Qualia Focus.


    Product Description
    Ingredients:Performance Lab Mind uses active ingredients like citicoline, phosphatidylserine, Amino acid, and maritime pine bark extract to achieve the best brain benefits
    Key Benefits:
  • Boost brain energy by up to 13.6%
  • Support focus and memory and boost motivation
  • Improve mental performance
  • Quantity:30 capsules
    Dosage:Take two capsules daily
    Assurance:30-day refund policy
    Mind Price: $69

    The aptly named Mind from Performance Lab is a nootropic supplement with clean packaging and effective formula. Ingredients like maritime pine bark extract and -L-Tyrosine (Amino Acid) are highly beneficial for brain protection. Together, the nootropics stack of Performance Lab Mind gives your body the antioxidants, vitamins, minerals, and other nutrients needed to support cognition in various ways.

    Brain Boost

    Product Description
    Ingredients:Brain Boost contains ingredients like Bacopa monnieri, Ginkgo Biloba, ashwagandha, cat’s claw extract, and lion’s mane mushroom
    Key Benefits:
  • Help support memory, blood flow, and cognitive function
  • Enhance mental clarity, focus, and immunity
  • Boost natural energy, mood, stress, and even your gut microbiome
  • Quantity:120 capsules
    Dosage:Take four capsules daily
    Brain Boost Price: $48

    Brain Boost from Vital Plan is a nootropic supplement created by Dr. Bill Rawls, MD. The supplement has transparent labeling, potent dosages, and zero proprietary formulas, which is why it’s one of the best nootropics of 2021. Plus, with four capsules per serving, Brain Boost is one of the most potent formulas on our list for those who want noticeable effects on brain function.


    Product Description
    Ingredients:the primary ingredients are NeuroFactor (Coffee Fruit), Cognizin (Citicoline), Sensoril (Withania Somnifera) and Activin (Grape Seed)
    Key Benefits:
  • Restore brain energy and increase BDNF levels
  • Prevent oxidative stress and support healthy cortisol levels
  • Promote neural communications
  • Quantity:30 servings
    Dosage:Add one scoop daily to your beverage
    Assurance:60 days money-back guarantee
    NeuroActiv6 Price: $46 per month

    NeuroActiv6 is a powdered nootropic formula from NaturalCell. The formula uses a high-powered powder to support brain function and improve focus, among other benefits.

    If you’re looking for an easy way to boost brain consciousness by adding active ingredients to your daily smoothie, then NeuroActiv6 may be the right choice for you. NeuroActiv6 won’t break the bank compared to other natural nootropics on our list.

    Synapse XT

    Product Description
    Ingredients:Hibiscus, Hawthorn Berry, Garlic and specific B-Vitamins, Rosemary, Magnesium, and Potassium
    Key Benefits:
  • Older adults can support hearing, memory, and focus by communicating between cells
  • Minimize the signs of mental fatigue
  • Improve cognitive function and mental performance
  • Quantity:60 capsules
    Dosage:Two capsules every day
    Synapse XT Price: $69

    Synapse XT uses a blend of herbs, vitamins, minerals, and plant-based ingredients to support long-term brain health and hearing health. If you’re an older adult experiencing hearing and cognitive issues, this nootropic stack claims to support both. The West Jordan, Utah-made nootropic supplement may be the right choice for those needing to support brain and hearing health.

    NooCube Brain Productivity

    Product Description
    Ingredients:Key ingredients in NooCube Brain Productivity include Alpha GPC, Huperzine A, cat’s claw extract, and Bacopa monnieri
    Key Benefits:
  • Ensure healthy brain function
  • Boost cognitive abilities and mood
  • Enhance mental processing speed
  • Quantity:60 capsules
    Dosage:Serve two capsules regularly every day
    Assurance:60-day money-back guarantee
    NooCube Brain Productivity Price: $60

    NooCube Brain Productivity is a nutritional supplement developed by top neuroscientists. Unlike many other brain supplements and nootropic stacks, NooCube’s Brain Productivity contains no caffeine. Instead, it uses unique herbal extracts, plant extracts, and other active ingredients to support cognition in various ways.


    Product Description
    Ingredients:NeuroFuel uses active ingredients like artichoke extract, forskolin, acetyl L-carnitine, vitamin B6, and L-phenylaniline per serving
    Key Benefits:
  • Boost focus and deep concentration
  • Enhance brain function
  • Support nerve growth factor
  • Quantity:45 capsules
    Dosage:Serve three capsules daily
    NeuroFuel Price: $30

    NeuroFuel from Natural Stacks is a nootropic supplement that targets brain fog, cognition, memory, and more. Although NeuroFuel is similar to other nootropics listed here, it has a unique advantage over competing formulas: The nootropic stack traces all ingredients and sources on the blockchain, making it the only “open source” nootropic listed here.

    Mind & Mood

    Product Description
    Ingredients:Rhodiola Rosea, 5-HTP, GABA, saffron, and L-theanine, and others
    Key Benefits:
  • Improve focus and concentration
  • Support brain cells for better signaling
  • Reduce stress and anxiety
  • Quantity:90 capsules
    Dosage:Take two capsules daily
    Assurance:60-day money-back guarantee
    Mind & Mood Price: $57

    Mind & Mood is a brain health supplement from UpWellness. While other nootropic supplements listed here support cognition, memory, and focus.

    By taking Mind & Mood smart drugs daily, you can purportedly enjoy a calmer, more relaxed nervous system. Formulated by Dr. Joshua Levitt and Dr. Amanda Levitt, Mind & Mood is also one of the few formulas on this list created by real doctors.


    Product Description
    Ingredients:The formula contains substantial doses of acetyl l-carnitine (500mg), Bacopa monnieri extract (300mg), and ashwagandha (200mg), along with smaller amounts of Rhodiola Rosea extract, Chinese club moss extract (with Huperzine A), and amino acids
    Key Benefits:
  • Provide healthy stress response
  • Boost mood and brain function
  • Improve mental performance and focus
  • Quantity:30 tablets
    Dosage:Take two tablets daily
    Assurance:90-day refund policy
    BrainEssence Price: $30

    BrainEssence is a nootropic supplement from PureEssence that supports memory, focus, energy, clarity, and mood. The supplement comes in the form of a tablet – not a capsule. PureEssence discloses all ingredients and dosages upfront, making it easy to see exactly what you’re putting into your body with each serving of BrainEssence.

    PureHealth Research Ageless Brain

    Product Description
    Ingredients:The supplement uses B vitamins, GABA, caffeine, and Huperzine A, among other ingredients
    Key Benefits:
  • Supercharge cognition in various ways
  • Decrease anxiety and brain fog
  • Improve focus and boost memory retention
  • Quantity:30 capsules
    Dosage:Take one capsule daily
    Assurance:One-year satisfaction guarantee
    PureHealth Research Ageless Brain Price: $44

    There are two ‘Ageless Brain’ supplements on our list. The second supplement comes from PureHealth Research. PureHealth Research’s Ageless Brain is a nutritional supplement formulated by Dr. Holly Lucille.

    Brain C-13

    Product Description
    Ingredients:The supplement comprises DMAE, Rhodiola rosea extract, rosemary leaf, turmeric, ginkgo leaf, Huperzine A, and phosphatidylserine, among other ingredients
    Key Benefits:
  • Improve concentration and focus
  • Boost cognitive health and brain function
  • Lower stress and overwhelming
  • Quantity:90 capsules
    Dosage:Three capsules daily
    Assurance:6 months money-back guarantee
    Brain C-13 Price: $49

    Brain C-13 from Zenith Labs is a nootropic supplement containing vitamins, minerals, herbs, and plant extracts similar to other formulas listed here.

    Zenith Labs discloses all ingredients and dosages upfront, making it easy to compare the formula to other top-ranked nootropics listed here. Like other Zenith Labs supplements, Brain C-13 is formulated by doctors and supported by a medical advisory board.

    Cymbiotika Golden Mind

    Product Description
    Ingredients:Each serving of these smart drugs contains ingredients like organic phosphatidylcholine, lion’s mane mushroom powder extract, Amino Acid, and L-theanine, among other ingredients
    Key Benefits:
  • Eliminate brain fog and enhance cognitive performance
  • Boost blood flow
  • Promote nurture brain cell growth
  • Quantity:30 servings
    Dosage:Take 14 pumps daily
    Cymbiotika Golden Mind Price: $50

    Golden Mind from Cymbiotika is the only nootropic formula on this list that comes in a liquid tincture instead of a powder or capsule. Golden Mind contains ingredients we don’t see in other cognitive enhancers, including sea buckthorn oil, Like lion’s mane mushroom, Gotu kola extract, and a combination of 82 ocean minerals, among other unique natural ingredients.

    Elm & Rye Nootropics

    Product Description
    Ingredients:Each serving of Nootropics contains GABA, bacopa monnieri extract, alpha GPC, L-theanine, L-tyrosine (Amino Acid), B vitamins, and phosphatidylserine extract, among other natural ingredients
    Key Benefits:
  • Improve memory and focus
  • Increase productivity and stamina
  • Strengthen cognitive function
  • Quantity:60 capsules
    Dosage:Serve two capsules daily
    Assurance:30-day risk-free guarantee
    Elm & Rye Nootropics Price: $85

    Elm & Rye sells a nootropic supplement called Nootropics. Nootropics are the highest-priced option on our list. You get a surprisingly strong dose (268mg) of caffeine per serving, which is like drinking 2 to 3 cups of coffee at once. For an instant jolt combined with other proven nootropics and smart drugs, Elm & Rye Nootropics may be the right choice for you – even at the higher price point.


    Product Description
    Ingredients:Shen Bu Xin San formula and Chaihu-Shugan-San formula
    Key Benefits:
  • Improve brain health and cognitive function
  • Enhance mental clarity
  • Boost learning, memory, and focus
  • Quantity:60 capsules
    Dosage:Take two capsules
    Assurance:One-year money back guarantee
    CogniBiotics Price: $62

    CogniBiotics works similar to any other nootropic supplement on this list. Unlike any other nootropic, however, CogniBiotics works by optimizing digestion – not by explicitly targeting your brain.

    Bad gut health can lead to impaired cognition. Your gut bacteria play a surprisingly crucial role in brain performance. CogniBiotics contains 17 nootropic and adaptogenic herbs that boost cognitive function, mood, and stress by improving gut flora. If you want to support brain health uniquely compared to other nootropic supplements listed here, then CogniBiotics may be the right choice for you.

    Amy Myers MD NeuroLive

    Product Description
    Ingredients:Vitamin B6, proprietary blend of bacopa monnieri whole plant extract, mucuna pruriens seed extract, ginkgo biloba leaf extract, sharp-PS GREEN Phosphatidylserine, and N-Acetyl Tyrosine/L-Theanine
    Key Benefits:
  • Boost brain health and natural cognitive function
  • Help in new brain cell development
  • Reduce free radicals and oxidative stress
  • Quantity:60 capsules
    Dosage:Take two capsules daily
    Assurance:90 days money-back guarantee
    NeuroLive: $49.97

    NeuroLive by Amy Myers MD is a doctor-formulated and recommended nootropic brain booster supplement that acts as a premium cognitive enhancer. With professional physician care and seven high-profile brain-supporting micronutrients, the NeuroLive nootropic formula makes a strong case for why it isn’t one of the most effective products on the market today.

    With free shipping and third-party lab tests for all of its NeuroLive nootropic supplements, users may expect sharp cognitive function by consuming enough ‘brain food’ to make a big difference right away in memory and focus.


    Product Description
    Ingredients:Natural caffeine, L-theanine, and B-vitamins
    Key Benefits:
  • Make you feel energized and calm
  • Improve focus and brain function
  • Enhance your cognitive functions
  • Quantity:9 pieces
    Dosage:Take one gum daily
    Assurance:100% happiness guarantee
    Neuro Price: $21+

    Neuro sells three gums and mints, including Energy & Focus, Calm & Clarity, and Ideal State. Whether looking to boost energy in the morning, optimize mood and clarity in the afternoon, or enjoy an overall sense of wellbeing throughout the day, Neuro may be the right choice for you.


    Product Description
    Ingredients:OptiMind’s principal active ingredient is Bacopa monnieri with 55% bacosides
    Key Benefits:
  • Boost energy and cognition functions
  • Support focus and mental clarity
  • Enhance mental and physical performance
  • Quantity:32 capsules
    Dosage:Take two capsules daily
    OptiMind Price: $30

    OptiMind is a mental energy, focus, and cognition supplement. Bacosides are the active chemicals within the Bacopa monnieri plant that give it its purported benefits. Taking the bacopa monnieri in OptiMind daily allows you to enjoy powerful cognitive support benefits and other effects.

    Youthful Brain

    Product Description
    Ingredients:Vitamin B12, Bacopa monnieri, and Huperzine A
    Key Benefits:
  • Support mental energy
  • Provide various cognitive benefits
  • Promote overall brain health using multiple active ingredients
  • Quantity:60 capsules
    Dosage:Take two capsules daily
    Assurance:6 months guarantee
    Youthful Brain Price: $65

    Youthful Brain is a nootropic supplement created by Vitality Now. Overall, Youthful Brain contains similar ingredients to other leading nootropic formulas on this list. However, this brain supplement has lower dosages and a higher price tag, which pushes it further down our list of the best-rated nootropic supplements of 2021.

    Oweli Neuro

    Product Description
    Ingredients:Key ingredients include Huperzine A, bacopa monnieri, phosphatidylserine, B vitamins, inositol, and DMAE, similar to other formulas listed here
    Key Benefits:
  • Support concentration
  • Improve mental function
  • Aids in memory, mood, stress, and productivity
  • Quantity:60 capsules
    Dosage:Take two capsules daily
    Assurance:100-day money-back guarantee
    Oweli Neuro Price: $30

    Oweli Neuro Brain & Focus Formula, also known simply as Neuro, is a unique nootropic that promotes Zen-like focus. By taking two capsules of Neuro daily, you can purportedly support improved memory and learning, support neuroplasticity, and help fight age-induced cognitive decline, among other benefits.

    ReMind Solution

    Product Description
    Ingredients:Phosphatidylserine, L-glutamine, Ginkgo Biloba, Bacopa Monnieri, N-acetyl L-carnitine (NAC or NALC), Huperzine A, and Vinpocetine
    Key Benefits:
  • Fight anxiety and stress
  • Prevent slow cognitive decline and focus problems
  • Improve brain function
  • Quantity:30 capsules
    Dosage:Take a single capsule daily
    ReMind Solution Price: $69

    PReMind’s main drawback is the price and value: the supplement provides few advantages over other brain supplements at this price range, yet it charges a premium price tag.

    Nevertheless, ReMind is making it easy to request a refund if you’re unsatisfied with the effects of the formula. Plus, further discounts are available when ordering 3 or 6 bottle packages of the formula.

    Brain Pill

    Product Description
    Ingredients:Citicoline, Amino acid, L-theanine, and vitamin B12
    Key Benefits:
  • Stimulates Cognitive function
  • Avoid brain fog and fight mental fatigue,
  • Protect and boost memory
  • Quantity:60 capsules
    Dosage:Serve two capsules of Brain Pill daily
    Assurance:67 days money-back guarantee
    BrainPill Price: $69.95

    Marketed as an “unfair advantage” over the competition, Brain Pill claims to eliminate a lot of brain issues. Each serving of Brain Pill contains 13 nootropics for all-day focus without the crash. Recommended by Dr. Dave David, Brain Pill claims to boost cognition with no unwanted side effects or jitters.

    The Brain Pill company claims to use “hefty doses” and “proper doses” of active ingredients without disclosing complete dosage information upfront, which puts it a tier below the best nootropic supplements on our list.

    ProMind Complex

    Product Description
    Ingredients:Key ingredients in ProMind Complex include L-glutamine, phosphatidylserine, bacopa monnieri extract, vinpocetine, and Huperzine A
    Key Benefits:
  • Improve brain function
  • Support memory retention
  • Boost your mental performance and stability
  • Quantity:30 capsules
    Dosage:Take one capsule daily
    Assurance:60 days money-back guarantee
    ProMind Complex Price: $69

    ProMind Complex is a nootropic formula created by a man named Carl Henderson. Carl claims to have used his decades of experience to formulate the perfect nootropic supplement. Although Carl and his team make the correct claims about the formula, ProMind Complex falls short based on its active ingredients and dosages.

    Memory Hack

    Product Description
    Ingredients:Bacopa Monnieri, Green tea, Artichokes Leaf, Omega Fatty Acid, and others
    Key Benefits:
  • Improve memory recall
  • Increase energy levels
  • Boost your mood
  • Quantity:60 capsules
    Dosage:Consume two capsules every day
    Assurance:180 days money-back guarantee
    Memory Hack Price: $69

    Memory Hack is a cognitive supplement made by Nutrition Hacks. Memory Hack is priced higher than many competing dietary supplements listed here, yet it doesn’t have the ingredients or dosages to support that price tag.

    The company claims people with memory problems can expect “total restoration of memory in six months.” Few nootropic supplements make claims like this, and Nutrition Hacks may give people with memory disorders unrealistic expectations about the effects.


    Product Description
    Ingredients:Phosphatidylserine, out N-Acetyl-L-Carnitine, Bacopa Monnieri Extract, and others
    Key Benefits:
  • Repairs damaged brain cells and eliminate brain shrinkage
  • Gets rid of anxiety and insomnia to boost your energy levels
  • Optimize your entire health and wellbeing
  • Quantity:30 capsules
    Dosage:Take one capsule daily
    Assurance:60 days money-back guarantee
    MemoSurge Price: $69

    MemoSurge is a nutritional supplement that claims to work in a three-step process. First, the supplement fires up neurotransmitters in your brain. MemoSurge provides limited information about its ingredients, concentrations, or dosages, making it difficult to compare the formula to other supplements listed here. MemoSurge may provide powerful benefits with few downsides, although the company offers limited information to support these claims.

    Memo Defend

    Product Description
    Ingredients:The formula’s core consists of a 620mg proprietary blend with Hawthorn leaf, garlic bulb, and olive leaf
    Key Benefits:
  • Support cognitive function
  • Avoid brain fog
  • Hep in memory retention and mental performance boost
  • Quantity:60 capsules
    Dosage:Take two capsules every day
    Assurance:60 days money-back guarantee
    Memo Defend Price: $69

    Made by a researcher named Thomas Taylor, Memo Defend is a nootropic supplement that uses natural ingredients to support cognition in various ways.

    Like other low-ranked nootropics supplements on our list, Memo Defend has limited information about its ingredients, dosages, or lab testing. The most critical ingredient in Memo Defend is vitamin B12 – an ingredient you can get in any nutritional supplement sold online today.

    How the Best Nootropics and Top Smart Drugs Ratings Work

    All nootropic supplements make similar promises, but only the best nootropics live up to those promises. After combing through lab reports, consulting with our team, contacting manufacturers, and doing other due diligence, here’s how our editorial team ranked the best nootropic supplements above:

    Science-Backed Ingredients

    Certain ingredients in nootropics and smart drugs have been proven to support cognition in multiple studies. After decades of research, we have plenty of evidence proving that plant extracts, vitamins, minerals, and herbal extracts can boost brain power in most people when taken in specific dosages. We preferred nootropics with science-backed ingredients and dosages, and we ranked these dietary supplements at the top of our list.

    Effective Dosages

    Many nootropic supplements contain the right ingredients at the wrong dosages. For example, a formula might have a dozen effective ingredients, yet the doses are too small to affect the human body significantly.

    Transparent Advertised Benefits

    Some nootropic companies exaggerate their benefits. They claim their formulas will make your brain decades younger, for example, and supercharge your memory and cognition, among other benefits. The best nootropic companies are honest and transparent with their advertised usefulness.

    Proprietary Blends

    Many supplements contain proprietary blends. In the nootropic space, however, proprietary blends are frequently used to hide weak dosages. Some companies even use proprietary blends to hide stimulants like caffeine. You might think a nootropic supplement is supercharging your cognitive energy – when you’re just getting a 250mg dose of caffeine hidden within a 300mg proprietary blend.

    Doctor Formulated or Approved by a Medical Advisory Board

    Some of the leading nootropic supplements are formulated by real doctors, including medical doctors (MDs) or naturopaths (NDs). An in-house medical advisory board approves others. The more professional certifications a nootropic had, the higher we ranked it.

    Manufacturer Reputation & Lab Testing

    Some manufacturers partner with third-party labs to test their formulas. Other manufacturers have decades of experience creating effective supplement formulas. Although we preferred manufacturers with a proven reputation for producing quality products, we weren’t biased towards older companies.

    Customer Reviews & Subjective Experiences

    Even the best nootropic supplement won’t work for everyone. That’s why we compared customer reviews and subjective experiences among our editorial team. We considered these reviews in our ratings.

    Price & Value

    Some people want to spend $200 per month on nootropic supplements. Others are looking for an edge for $20 per month. We preferred nootropic supplements with good value at any price. Whether looking to spend a few dollars or a few hundred dollars per month to support brain health, we listed a range of supplements for you.

    Clinical Trials & Peer-Reviewed Research

    Most nootropic supplement companies do not invest in clinical trials. Clinical trials are expensive and take a long time. However, as nootropics have become more popular, some companies have invested in clinical trials or published research in peer-reviewed journals, giving these companies an extra layer of legitimacy over competing nootropic supplement companies.

    Money-Back Guarantee

    The best nootropic supplement companies stand behind their formula with a money back guarantee. We preferred supplement companies that offered a satisfaction guarantee, money back guarantee, or similar promises to ensure the formula worked as advertised.

    Nootropic Supplement Benefits: What Does Science Say?

    Nootropic supplement companies make bold claims about their effects and benefits. But do nootropic supplements work? How do nootropics work? What does science say about nootropics? Do clinical trials and peer-reviewed research back nootropics?

    A few years ago, nootropics was an emerging field with little research. Today, you can find peer-reviewed research supporting specific nootropic formulas. Some of the best nootropic supplement ingredients are backed by decades of research in animals and humans. We’ll review some of that research below.

    Bacopa monnieri is one of the most-studied nootropic ingredients available. In this 2008 study, researchers found that a 300mg dose of Bacopa monnieri safely enhanced cognitive performance in older adults.

    Ginkgo biloba is another popular herbal extract found in many leading nootropics. Like Bacopa monnieri, ginkgo Biloba is backed by centuries of use in traditional Chinese medicine. It’s also backed by modern scientific research. In this 2001 study, researchers gave ginkgo Biloba and vinpocetine (another nootropic ingredient) to participants for 14 days. Researchers observed faster response times and better memory in the ginkgo Biloba group compared to the placebo.

    Ashwagandha is popular in Ayurvedic (traditional Indian) medicine, where it’s been used for relaxation, cardiovascular health, sleep, stress management, and more for centuries. In this 2016 study, researchers reviewed dozens of studies on ashwagandha and concluded the formula had “nootropic potential.”

    L-theanine is part of the world’s most popular nootropic stacks: many people take caffeine and L-theanine daily to support cognition. L-theanine may nullify the adverse effects of caffeine, giving you all of the energy-boosting benefits of caffeine with none of the jitters or anxiety.

    Onnit Alpha Brain is one of the few nootropic supplements that has completed major clinical trials. In this 2016 study published in Human Psychopharmacology, researchers gave Onnit Alpha Brain to 63 participants between 18 and 35. Participants received either Onnit Alpha Brain or a placebo over six weeks. Researchers found the Alpha Brain group “significantly improved verbal memory” and executive functioning compared to the placebo group.

    Overall, the best nootropic supplements available today use proven ingredients to support cognition, mood, memory, and more. Look for science-backed ingredients and dosages to ensure you’re maximizing the benefits of your nootropic formula.

    Nootropic Dosages

    Nootropic supplements contain a blend of different ingredients. Follow the recommended dosage instructions on your nootropic supplement.

    Check your nootropic label for a proprietary formula. Most reputable nootropic supplements disclose individual dosages. However, some companies continue to use proprietary labels. If you’re sensitive to caffeine, and if your nootropic supplement uses a proprietary formula containing caffeine, then be careful when using your nootropic supplement.

    FAQs About Nootropics

    Q: What is a nootropic?

    A: A nootropic is a drug, supplement, food, beverage, or other consumable used to boost cognitive ability.

    Q: What do nootropics do?

    A: Nootropics support brain function in different ways. Some nootropics and smart drugs boost memory and cognition. Others increase energy by acting as a stimulant. Some even improve executive functioning or adjust brain plasticity in unique ways.

    Q: What’s the best nootropic?

    A: Any of the top-rated nootropic formulas on our list are among the best nootropic supplements available in 2021.

    Q: Are nootropics safe?

    A: By law, all nootropic supplements sold online today contain ingredients Generally Recognized As Safe (GRAS) by the FDA. When following the recommended dosage instructions on your brain supplement, you’re unlikely to experience safety issues or severe side effects. However, when making your nootropics, combining nootropics supplements with drugs, or experimenting with dosages, nootropics could become unsafe. You should also talk to your doctor before taking a brain supplement if you have a medical condition or take any medication.

    Q: Why should I take a nootropic supplement? What are the benefits?

    A: People take nootropic supplements to boost memory, brain cells, cognition, and overall brain power. Some people are targeting a specific issue – like memory problems. Others are looking for general cognitive support with these smart drugs.

    Q: Who can avail brain health benefits from a nootropic supplement?

    A: Athletes, people who work in competitive environments, college students, entrepreneurs, busy parents, older adults, and anyone looking for a cognitive edge can all benefit from a good nootropic supplement.

    Final Word on the 33 Best Nootropics and Brain Booster Supplements

    Above mentioned best nootropic supplements and smart drugs are more popular than ever. You have more nootropic formulas available today than at any previous point in history.

    Today, you can easily and cheaply buy popular nootropic formulas at major online and offline retailers. A good nootropic supplement optimizes memory, cognition, executive functioning, and more.

    Whether you’re an older adult, an athlete, a worker in a competitive office, a student looking for an edge, or anyone else who wants to optimize brain power, any of the top-ranked nootropic supplements on our list may be the best choice for you. Without question, this is one of the most extensive nootropic reviews ever crafted, so make sure to bookmark this page as there will be plenty of updates to share with the latest customer success stories and even complaints about negative side effects or adverse reactions. The list for the top 33 best nootropic supplements for brain-boosting cognitive performance enhancement offers something for everyone as it is a detailed collection of the very finest smart pills and nootropic stacks available today.

    RELATED:Best Hearing Supplements: Top Ear Health Products for Hearing Loss

    Affiliate Disclosure:

    The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


    Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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