DNA finding widens marrow donor field

Associated Press

SEATTLE — Advanced DNA technology is helping researchers identify bone-marrow or stem-cell donors once thought unsuitable for cancer-fighting transplants.

Scientists at Fred Hutchinson Cancer Research Center and the University of Washington have discovered that certain genetic "mismatches" between donors and patients will not cause transplants to fail, as previously believed.

The discovery, reported in Thursday’s edition of The New England Journal of Medicine, could help save hundreds of patients a year who seek new bone marrow or stem cells to fight off leukemia or other cancers.

"By understanding that certain mismatches are very well tolerated, more patients can benefit from a lifesaving transplant," said Dr. Effie Petersdorf of the Hutchinson Center, who directed the research.

The researchers used DNA sequencing to determine the exact tissue type of 471 Hutchinson-center patients with chronic myelogenous leukemia who received bone marrow transplants from unrelated donors between 1985 and 2000.

Examining transplant failures, researchers found no higher a failure rate in patients with a single gene mismatch than those with perfectly matched marrow.

"It showed us a patient shouldn’t be denied a transplant because a perfectly matched donor can’t be found," Petersdorf said.

The Seattle Cancer Care Alliance — a collaboration of the Hutchinson center, the UW and Children’s Hospital and Regional Medical Center — is regularly using DNA technology to identify bone marrow and stem cell donors, Petersdorf said.

The DNA technology used in the Seattle study is based on the same principles used in crime analysis of blood and other cellular material. It examines the sequence of DNA, or genetic code, to determine whether a gene is a match or near-perfect match.

DNA in bone-marrow tissue or stem cells that transplant patients receive must be as closely matched as possible to their own genetic material so their immune systems won’t reject the transplants.

Such transplants are given so that new blood cells produced will not be diseased, as they are in leukemia patients.

At any given time, about 3,000 cancer patients worldwide are searching for unrelated bone marrow or stem cell donors.

Copyright ©2001 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

Talk to us

> Give us your news tips.

> Send us a letter to the editor.

> More Herald contact information.

More in Local News

A Cessna 150 crashed north of Paine Field on Friday evening, Feb. 16, 2024, in Mukilteo, Washington. The pilot survived without serious injury. (Courtesy of Richard Newman.)
‘I’m stuck in the trees’: 911 call recounts plane crash near Paine Field

Asad Ali was coming in for a landing in a Cessna 150 when he crashed into woods south of Mukilteo. Then he called 911 — for 48 minutes.

Everett
Snohomish County likely to feel more like winter, beginning Monday

Get ready for a mix of rain and snow this week, along with cooler temperatures.

Anthony Boggess
Arlington man sentenced for killing roommate who offered shelter

Anthony Boggess, 33, reported hearing the voices of “demons” the night he strangled James Thrower, 65.

Mt. Pilchuck covered in snow is barely visible through the clouds as the sun breaks through illuminating raindrops as they fall off of the Mountain Loop Highway on Wednesday, Feb. 7, 2024 in Granite Falls, Washington. (Olivia Vanni / The Herald)
‘Active’ weather brings rain, snow, hail, fresh powder to Snohomish County

Up to an inch of snow could accumulate in the lowlands. Three inches of rain could fall in Darrington. And Stevens Pass is “doing quite well.”

Joanne Fisher, right, a meat wrapper with the Marysville Albertsons, hands a leaflet to a shopper during an informational campaign on  Wednesday, Nov. 9, 2022. Fisher was one of about a dozen grocery store workers handing out leaflets to shoppers about the proposed merger between Albertsons and Kroger. (Mike Henneke / The Herald)
US sues to block merger of grocery giants Kroger, Albertsons

Grocery workers in Snohomish County and elsewhere have argued the merger would stymie competition and hurt workers.

The Senate Ways and Means Committee during its meeting on Monday, Feb. 26, 2024, where the panel indicated it would not move ahead with legislation to cap residential rent increases at 7%. The move effectively killed the bill for the 2024 legislative session. (Bill Lucia/Washington State Standard)
Plan for 7% statewide cap on rent increases fails in Olympia

State Sen. June Robinson, D-Everett, told reporters the bill did not have enough support to move it forward.

People look out onto Mountain Loop Mine from the second floor hallway of Fairmount Elementary on Wednesday, Jan. 10, 2024 in Everett, Washington. (Olivia Vanni / The Herald)
Mining company ordered to stop work next to school south of Everett

After operating months without the right paperwork, OMA Construction applied for permits last week. The county found it still violates code.

Shoppers cross Alderwood Mall Parkway after leaving the mall and walking through its parking lot on Thursday, Feb. 15, 2024, in Lynnwood, Washington. (Ryan Berry / The Herald)
Lynnwood police seek 3 suspects after pursuit, brief shootout

The driver of a stolen car intentionally hit a teen boy Sunday, officers said. Police pursued the suspects near I-5.

Starbucks employee Zach Gabelein outside of the Mill Creek location where he works on Friday, Feb. 23, 2024 in Mill Creek, Washington. (Olivia Vanni / The Herald)
‘We cannot keep up’: Mill Creek Starbucks workers file for unionization

The cafe’s crew joins the ranks of the 624 stores nationwide, including two other locations in Snohomish County.

The Nimbus Apartments are pictured on Wednesday, March 1, 2023, in downtown Everett, Washington. (Ryan Berry / The Herald)
Snohomish County has the highest rent in the state. Could this bill help?

In one year, rent for the average two-bedroom apartment in Snohomish County went up 20%. A bill seeks to cap any increases at 7%.

The Westwood Rainier is one of the seven ships in the Westwood line. The ships serve ports in the Pacific Northwest and Northeast Asia. (Photo provided by Swire Shipping)
Westwood Shipping Lines, an Everett mainstay, has new name

The four green-hulled Westwood vessels will keep their names, but the ships will display the Swire Shipping flag.

A Snohomish County no trespassing sign hangs on a fence surrounding the Days Inn on Monday, Feb. 12, 2024 in Everett, Washington. (Olivia Vanni / The Herald)
Meth cleanup at Edmonds motel-shelter made matters worse, report says

Contamination has persisted at two motels Snohomish County bought to turn into shelters in 2022. In January, the county cut ties with two cleanup agencies.

Support local journalism

If you value local news, make a gift now to support the trusted journalism you get in The Daily Herald. Donations processed in this system are not tax deductible.