Children found to have higher levels of the pesticide malathion seem to be at an increased risk of attention deficit hyperactivity disorder, or ADHD, researchers reported today.
Several previous studies have linked neurodevelopmental and behavioral disorders such as ADHD to exposure to pesticides, but generally in children of farmworkers and others exposed to abnormally high levels of the chemicals.
The new study is the first to focus on “a population sample more representative of the United States, and not one selected for being at high exposure,” said epidemiologist Marc Weisskopf of Harvard University’s School of Public Health, the senior author of the paper in the journal Pediatrics.
Weisskopf and his colleagues speculated that for most of the children in their study, exposure came through food.
The 2008 report of the U.S. pesticide residue program found, for example, that 28 percent of frozen blueberries, 25 percent of strawberries and 19 percent of celery were contaminated with malathion.
ADHD is thought to affect 3 percent to 7 percent of children in the United States, with boys affected much more heavily than girls. Its prevalence is generally assumed to have increased sharply in the last three to four decades, but controversy exists about whether the incidence has increased or diagnostic standards have broadened.
Weisskopf and his colleagues studied data on 1,139 children from the government’s National Health and Nutrition Examination Survey for the period 2000 to 2004.
Among the information collected in the survey were the level of metabolites of malathion in urine and, through a structured interview with the parents, whether a child had been formally diagnosed with ADHD. There were 119 children diagnosed with ADHD.
Accounting for other factors, the researchers concluded that a tenfold increase in malathion metabolite levels in urine — still a very low level — was associated with a 55 percent higher risk of having ADHD.
The study has some obvious deficiencies. Unlike DDT and certain other pesticides, malathion is cleared from the body quickly, in three to five days, and levels can fluctuate widely.
Because the government health and nutrition survey is a “snapshot” of urine levels at one point in time, it says little about long-term exposures, Weisskopf conceded.
But if the children’s diets remain relatively constant over a long term, he said, then the findings are probably a reasonable estimate of normal levels.
Variations in exposure over long periods would make it harder to find an association, he added, so the fact that they found a link is significant.
Talk to us
> Give us your news tips.
> Send us a letter to the editor.
> More Herald contact information.
