Are your blood sugar levels highly variable? Have you noticed that this variability has created a rollercoaster of depression, agitation, happiness, temper, and low energy, among others? The significant factors contributing to this concern can include diets high in sugar, sleep and emotional disturbances, dehydration, certain beverages, and excess physical activity, to list a few. Dietary changes are one way to prevent dramatic fluctuations in blood sugar. Switching out low-quality (or simple) carbohydrates to complex carbohydrates is superior, as individuals are now fueling their bodies with vitamins, minerals, and fiber.
Another option is to partake in physical activity daily for at most 45 minutes. This supposedly helps to increase insulin release and reduce insulin resistance. In addition to this duo, one team believes taking dietary supplements further accelerates healing or, in this case, management. To make blood sugar regulation seamless, this team recently launched the one and only Insutril®.
What is Insutril®?
Insutril® is a dietary tincture meticulously crafted to help individuals regain control over their blood sugar levels. The underlying formula consists of an all-natural proprietary blend of what the creators describe as “eight powerful ingredients backed by clinical research.” At first glance, our editorial team recognized many of the listed ingredients, as they have either been proven or touted for blood sugar benefits. In the grand scheme of things, this formula appears to blend scientific evidence with traditional practices in an elegant manner, which is a rare sight.
Is one superior to the other when it comes to Insutril®? Is Insutril® as powerful as the creators make it out to be? Is Insutril® a safe alternative to the common recommendations that society gives? These are all reasonable questions, especially for those directly impacted by fluctuating blood sugar levels and/or who have a pre-existing medical condition. Our goal is to answer many unknowns and help individuals make informative decisions.
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What are the main ingredients in the Insutril® formula?
After reviewing the facts about the Insutril® supplement, it became clear that it contains eight main ingredients, with the rest serving as additional support. More specifically, we are referring to ingredients such as:
Gymnema Sylvestre
Gymnema sylvestre (or gurmar) is a climbing plant from the Apocynacaea family. It is one of many staples in Indian Ayurvedic medicine, as its leaves contain a therapeutic bioactive compound called gymnemic acid. Its primary role entails regulating blood sugar levels, which is achieved through different mechanisms. For starters, gymnemic acid has been proven to mask sweet tastes, reduce one’s desire for them, and keep sugar levels from dramatically reacting.
Next, gymnema sylvestre might increase insulin production by promoting pancreatic cellular growth. Alas, research on this specific angle is limited, preventing us from making firm conclusions. Following suit, some studies have proven that the plant lowers the amount of sugar absorbed by the intestines. This is especially important considering the implications for gut health, digestive health, and blood sugar.
A more recent study confirmed that gymnema sylvestre possessed anti-diabetic properties, adding that the results were “comparable with the anti-diabetic effect of standard drug metformin.” Finally, other health areas that might positively improve in the presence of gymnema sylvestre include cholesterol (reducing low-density lipoprotein and increasing high-density lipoprotein) and fat-lowering processes.
Banaba Leaves
Banaba leaves have been a staple in folk medicine for centuries. They are renowned for their anti-diabetic, antioxidant, anti-inflammatory, antiobesity, and cholesterol-lowering properties. These properties are associated with the plant’s two main bioactive compounds: corosolic acid and ellagic acid. As for its anti-diabetic activity, one source underscored that the effects are attributed to both corosolic acid and ellagitannins, insisting that the duo lowers blood sugar levels by participating in “glucose regulation and metabolism, including enhanced cellular uptake of glucose, improved insulin sensitivity, decreased gluconeogenesis, and inhibited intestinal hydrolysis of sucrose.”
Interestingly, the same source pointed out that a study also demonstrated weight loss results. Specifically, taking 10 mg of corosolic acid as a Banaba extract standardized to 18% corosolic acid daily for 2 weeks led to a 12% drop in fasting blood sugar and post-meal blood sugar (60 minutes later). At the time, the authors reported an average weight loss of 3 lbs, which is marginal but a push in the right direction nonetheless.
Finally, a recent randomized, double-blinded, placebo-controlled crossover trial looked at the effects of corosolic acid on glucose and insulin responses in non-diabetic middle-aged men with impaired fasting glucose. By the end, the researchers discovered that the bioactive compound improved glucose tolerance, post-meal glucose, insulin sensitivity, and how the liver responds to insulin. The latter is an imperative pathway to regulate blood sugar levels by storing or releasing glucose as required.
That said, the recent study is small and might need to be replicated with a larger sample of diverse demographic backgrounds. However, the key takeaway is that corosolic acid continues to be shown as a prospective adjunct therapy.
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Bitter Melon
Bitter melon is a plant native to Asia, South America, the Caribbean, and East Africa. It boasts a vegetable — at least that’s how it’s been treated in many cultures — that gets bitter as it ripens. According to the same source, bitter melon’s link to lowered blood sugar levels is due to its properties, which act like insulin. In other words, its constituents help transport glucose into the cell, liver, and muscles for energy. Although there is evidence in favor of blood sugar management, it remains unused as a possible adjunct therapy for prediabetes or diabetes, explains the authors.
This might be due to the fact that researchers still want to see more studies to assess its effect on type 2 diabetes and how to properly integrate bitter melons into nutrition therapy. A newer study delved deeper into the properties of bitter melon, trying to pinpoint the exact constituent with insulin-like activity. Finally, the researchers discovered a specific sequence of 19 amino acids called mcIRBP-19, which might bind to the insulin receptor to lower blood glucose. In their study, 142 diabetic patients over the age of 20 were recruited and split into the experimental (n = 64) and control (n = 78) groups.
Subjects in the experimental group were required to take a 300 mg capsule twice daily (before lunch and dinner). In the end, researchers found that taking bitter melon (namely, the extract with the 19 amino acid sequence) significantly improved the blood sugar levels of diabetic patients after the first month of use. Of course, this isn’t to say that bitter melon pills should be used instead of an existing medication, but possibly as an adjunct. As for limitations, this study only consists of Taiwanese people and failed to assess HbA1c levels.
Licorice Root
Licorice root comes from the root of the Glycyrrhiza glabra plant, which is native to Asia, Southern Europe, and the Middle East. It contains over 300 compounds, with its primary constituent being glycyrrhizin, which possesses antioxidant, anti-inflammatory, and antimicrobial properties. One review aimed to provide an overview of the characteristics and mechanisms of licorice for treating diabetes. Interestingly, the researchers found that five flavonoids and three triterpenoids derived from licorice carry the greatest anti-diabetic activities in vivo and in vitro.
In particular, these constituents are believed to increase insulin sensitivity, enhance glucose uptake by different tissues and organs, clear away free radicals, and correct fat and protein metabolism issues, thereby improving blood flow in the body. As for the pathways that licorice compounds target to unleash these outcomes, they include P13K/Akt (plays a role in transporting glucose to cells), AMPK (promotes glucose uptake and fatty acid oxidation), AGE-RAGE (impairs insulin signaling), MAPK (influences insulin signaling and glucose metabolism), NF-kB (triggers inflammation and insulin resistance), and NLRP3 (activates inflammatory responses, leading to insulin resistance).
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Cinnamon Bark
Cinnamon is a spice made from the inner barks of the Cinnamomum verum tree native to Sri Lanka. There are two types: Ceylon and Cassia. Ceylon is considered the true cinnamon (since it is from Sri Lanka), whereas cassia is less expensive and normally found in most food products containing cinnamon. In the context of blood sugar management, this ingredient is believed to mimic the insulin hormone (i.e., transporting glucose into cells, liver, muscles, etc.) and increase insulin sensitivity.
It has also been shown to lower fasting blood sugar, hemoglobin A1c, and post-meal blood sugar levels. One thing to remember is that these results generally stem from a dose ranging between 1 and 6 grams taken over at least two months. So, which of the two types is more powerful? True cinnamon, explains the authors, as this type also contains potent antioxidants critical for neutralizing free radicals and taming oxidative stress and inflammation. More recently, a small study was conducted to determine the effect of daily cinnamon consumption in 18 adults with obesity and prediabetes.
Participants were split into the cinnamon and placebo groups and followed for 10 weeks. The researchers discovered that the cinnamon group’s glucose concentration significantly dropped after 24 hours, leading to lower glucose peaks and higher glucose-dependent insulinotropic polypeptide concentrations. These results led the researchers to conclude that cinnamon might aid in bettering glucose control for people with obesity-related prediabetes.
Chromium (from Brazil Nuts)
Chromium is a trace element believed to increase the effectiveness of insulin, thereby promoting carbohydrate, lipid, and protein metabolism. More specifically, chromium is alleged to bind to an oligopeptide, converting it to chromodulin and binding to and activating the insulin receptor. As such, individuals can anticipate lowered fasting serum glucose concentrations and hemoglobin A1c levels. However, a 2019 review referenced by the source [supposedly underlined the fact that many studies tested various doses (ranging between 1.28 and 1,000 mcg daily) and types and arrived at inconsistent findings.
The authors also noted that though statistical significance has been reached in numerous instances, the same cannot be said about clinical significance. Interestingly, chromium’s effectiveness might vary, having a stronger effect among people with severe insulin resistance and poorer glycemic control. Clearly, there remain many unanswered questions, so our editorial team continued digging for answers. Alas, very little confirmation is provided. Thus, there is potential, but high-quality studies are still needed to fully understand chromium’s usefulness as an adjunct treatment for diabetes.
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Juniper Berry
Juniper berries grow on the Juniperus communis evergreen shrub. They resemble the shape of blueberries but are often described as having a “tart, pine-like flavor.” Starting with their nutrients, these berries boast high antioxidant content critical for keeping inflammation, free radicals, and oxidative stress in check. Moreover, they contain monoterpenes, which possess anti-inflammatory, antifungal, and antibacterial properties. In the context of diabetes, there is some reason to believe that its antioxidant content might help reduce body weight and improve blood lipid profiles; however, human studies are still needed to confirm these results.
The latest in vivo and in vitro study examined the effects of juniper berries on peroxisome proliferator-activated receptors alpha and gamma (PPAR-a and PPAR-y), liver X receptor (LXR), glucose uptake, and lipid accumulation. The technicals aside, the researchers showed that juniper berries activated PPAR-a, PPAR-y, and LXR pathways without triggering adipogenesis or blocking glucose uptake. According to them, these berries possess anti-diabetic and antiobesity properties, possibly serving meaningful use in metabolic disorders and type 2 diabetes.
Cayenne
Cayenne peppers, or Capsicum annuum, are known for their hot, spicy flavor attributed to an active compound called capsaicin. When capsaicin is consumed in a high-dose supplement, some of the reported benefits include pain relief, heightened athletic performance, and lowered blood sugar levels. In digging further into the latter outcome, our editorial team came across a study that assessed capsaicin’s underlying mechanism in streptozotocin-induced diabetic rats. The researchers then found that it lowered blood sugar levels by increasing insulin and glycogen content. In other words, “the spicy characteristics of capsaicin might be the root of its ability to decrease blood glucose.”
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Frequently Asked Questions (FAQ)
Q: Is Insutril® safe?
A: Based on the research on the main ingredients, Insutril® might be generally safe to take. The blood-sugar-lowering ingredients have been mostly studied extensively, demonstrating promising strong evidence. Since this tincture is a proprietary blend, the chances of high doses per ingredient are rather slim. In fact, each dropper offers 200 mg of all the main and supporting ingredients. In this respect, the risk of side effects might be rather small. Moreover, the creators take pride in having a manufacturing process based in an FDA-registered, GMP-certified facility in the United States.
Having said that, pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition (and/or taking medication) are strongly recommended to consult a healthcare provider before using this supplement. Such consultation might provide more insight into the risk of side effects on an individualistic basis.
Q: Are there other ingredients in each Insutril® serving?
A: Yes, this formula also contains several supporting ingredients that either enhance the main ingredients or provide temporary relief for people suffering from symptoms of fluctuating blood sugar levels. These include Maca, Grape Seed Extract, Guarana, African Mango, eleuthero extract, Astragalus Extract, Green Tea Extract, Forskolii, Grapefruit Seed Extract, Asian Ginseng Root Extract, Raspberry Ketones, GABA, L-glutamine, L-tyrosine, L-arginine, and Beta-Alanine.
Q: Who is Insutril® suitable for?
A: Insutril® is considered suitable for adults of most ages suffering from dramatic variability in blood sugar levels.
Q: How do I take Insutril®?
A: According to the supplement’s facts, individuals are recommended to shake the tincture well and then take two full droppers daily. For optimal results, the solution should be placed directly in the mouth. Alternatively, these drops can be added to any beverage base of choice.
Q: What are the benefits of taking Insutril®?
A: The creators believe that Insutril® has the potential to make sweet foods less appealing, support antioxidant activity and metabolism, suppress appetite, increase insulin activity and insulin sensitivity, promote healthy digestion, and lower blood sugar levels.
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Q: How should I store Insutril®?
A: To maintain the integrity of the Insutril® formula, it is recommended that individuals store it away from heat, light, and humidity.
Q: How long will it take for Insutril® shipments to arrive?
A: Insutril® shipments to the contiguous United States usually take 5 to 7 business days, whereas international shipments take 10 to 15 business days, depending on the countries’ customs clearance procedures.
Q: Is Insutril® protected by a money-back guarantee?
A: Yes, each Insutril® purchase has been protected by a 180-day money-back guarantee to be more precise. This means individuals have 180 days from the purchase date to test this formula for themselves. If blood sugar levels aren’t stabilized as expected, then customer service can be contacted for a full purchase price refund. Requests must be made within the 180-day period to be eligible. For more information on the refund policy, consider one of the following communication channels:
- Email: cs@ogruposix.com.
- Phone: 1 (855) 495-3156
Ordering Insutril®
Each Insutril® tincture bottle contains 60 ml of substance intended for use over 30 days. Given that correcting for variability in blood sugar requires time, patience, and consistency, the creators have decided to slash prices by quantities purchased. This allows individuals to focus on lowering their blood sugar levels without worrying about the cost. With that, here is a quick rundown of the various prices:
- 1 Insutril® bottle: $69 each
- 3 Insutril® bottles: $59 each
- 6 Insutril® bottles: $49 each
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Final Verdict
Based on the analysis above, Insutril® is a blood sugar support intended to increase insulin action, lower fasting and post-meal blood sugar levels, improve hemoglobin A1c levels, reduce the implications of inflammation and oxidative stress, and lower blood sugar levels. Our research on the main ingredients shows a lot of promise, with evidence ranging from promising to strong. Many of these ingredients are commonly used in alternative medicine, particularly for managing blood sugar levels and weight.
In the past, people were less inclined to consider the plant-based approach due to the lack of scientific evidence. Fortunately, a continuously growing body of evidence supports these ingredients as adjunct therapies for blood sugar control and insulin efficiency. It is up to interested parties to use this review as a basis for a more comprehensive investigation (keeping in mind their health).
As promising and even reassuring as this tincture is, one might question its overall efficacy. The formula combines everything in a lower-dosed proprietary blend. Are smaller amounts of each ingredient together as potent as high doses of each individual ingredient? It’s hard to tell, as many factors influence this. For instance, supplement providers rarely disclose the exact breakdowns of ingredients in proprietary blends, making it difficult to investigate.
Furthermore, few studies have examined the combined effects of the ingredients. Until more research is available, this question will remain unanswered. Overall, Insutril® might be a worthwhile investment, but individuals are accountable for doing their own research.
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