Best Nerve Supplements (2023) Top Neuropathy Pain Relief Pills

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  • Friday, January 13, 2023 9:08am
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Neuropathy can cause tingling, pain, or numbness in your extremities.

Neuropathy is common in diabetics. About 65% of all people with diabetes have some type of nerve damage, leading to diabetic neuropathy. Diabetes is the leading cause of neuropathy in the United States.

You can develop neuropathy for other reasons. Some develop neuropathy because of physical damage to nerves, for example. In others, it’s a genetic condition.

Today, many people take nerve health supplements to help with neuropathy. Some nerve health supplements are proven to help with pain, inflammation, and other effects associated with neuropathy.

With so many nerve health supplements available, it’s tough to know which supplement is right for you. We’re here to help. Here are the best supplements for neuropathy in 2021.

Ranking the Best Nerve Health Supplements for Neuropathy Support

To rank the best nerve health supplements available, our editorial team tested and analyzed supplements, contacted manufacturers and labs, and painstakingly rated each supplement based on its effectiveness.

Here are our rankings of the best nerve supplements for 2021:

  • Nerve Control 911
  • Nuturn Maximum Strength Neuropathy Support Formula
  • Nervala
  • Nerve Renew
  • Nerve Rejuv
  • Nervexol
  • Circle Labs CBD
  • Nuturna Clinical Strength Neuropathy 900
  • Neuro Calm Pro
  • Nervogen Pro
  • Bonus Nerve Pain Guide #1: Neuropathy No More
  • Bonus Nerve Pain Guide #2: Neuropathy Revolution

Let’s jump right in and review the best supplements for neuropathy to find out which are the top nerve health support formulas today!

Nerve Control 911


PhytAge Labs, one of the longest standing health and wellness brands in the industry, makes a neuropathy supplement called Nerve Control 911. The supplement claims to target nerve pain linked to diabetes and other conditions using all natural ingredients that pack a real punch towards neuropathy. By taking two capsules of Nerve Control 911 daily, you can purportedly relieve certain symptoms of nerve pain. The natural supplement for neuropathy also claims to help improve the body’s muscles, control voluntary movements and reflexes, help transmit information from the central nervous system to the rest of your body, and reduce inflammation, among other effects.

Nerve Control 911 contains high profile natural ingredients like marshmallow root and passion flower. PhytAge Labs describes one ingredient in Nerve Control 911 as a “miracle root” from Malaysia. According to PhytAge Labs official presentation, one woman even “avoided amputation” by taking Nerve Control 911. That woman’s nerve damage was out of control before taking Nerve Control 911, and doctors warned her they needed to amputate. Nerve Control 911 “fixed it, within a matter of days,” according to PhytAge Labs, allowing the woman to continue living with all four limbs.

For many more reasons explained on the official Nerve Control 911 website, this nerve calming formula tops the list of the best nerve supplement to buy in 2021. But, it is worth comparing how this supplement for neuropathy stacks up against other top competitors that are all worthy considerations.

Price: $69.95

Nuturna Maximum Strength Neuropathy Support Formula


Nuturna’s Maximum Strength Neuropathy Support Formula is a powerful neuropathy support formula that continues to be one of the internet’s best-selling neuropathy supplements. Available for under $43 on Amazon, the Nuturna Maximum Strength Neuropathy Support Formula uses alpha lipoic acid, L-arginine, benfotiamine, turmeric, and herbal extracts to target nerve pain.

Despite being one of the most affordable supplements on this list, Nuturna’s Maximum Strength Neuropathy Support Formula has some of the strongest doses. Each four capsule serving contains 600mg of ALA, for example, which is a higher dose than most other supplements on this list. If you want to get the same dose of active ingredients used in clinical trials, then this is one of the best options. Many neuropathy supplements contain the right ingredients – but at the wrong dosages. With the Nuturna Maximum Strength Neuropathy Support Formula, you get a powerful formula with 18 herbs, vitamins, and minerals targeting nerve pain in various ways.

Price: $43



Barton Nutrition markets its Nervala supplement as “the secret to getting rid of tingling, numbness, [and] shooting pain. According to Barton Nutrition, Nervala works by “cooling down” your nerves, protecting you from the “overheating engines” that lead to nerve pain.

In more realistic terms, Nervala targets inflammation throughout your body. The supplement contains ingredients that support healthy inflammation by targeting free radicals. Free radicals cause oxidation and inflammation throughout your body. By targeting and neutralizing free radicals, Nervala can support healthy inflammation, which could help with neuropathy in some people. Each serving of Nervala contains just two active ingredients, including 75mg of benfotiamine and 600mg of alpha lipoic acid, both of which could help with neuropathy in various ways.

Price: $67

Nerve Renew


Life Renew’s Nerve Renew is an advanced nerve support supplement that uses B vitamins and alpha lipoic acid to relieve neuropathy. You take two capsules daily to target nerve damage. Nerve Renew works by flooding the nerve damage with antioxidants, helping to ease nerve pain, numbness, and discomfort in the region.

The full list of ingredients in Nerve Renew includes vitamins B1, B2, B6, B12, and D, among others. Life Renew claims their formula is absorbed by the body three times faster than competing neuropathy supplements because of its unique delivery mechanism. Just take Nerve Renew daily for natural nerve repair, fast-acting pain relief, a natural energy boost, and a reversal of numbness and tingling.

Price: $59

Nerve Rejuv


Nerve Rejuv from Golden After 50 is a neuropathy supplement marketed to older adults with nerve pain, including diabetics and non-diabetics. By taking two capsules of Nerve Rejuv daily, you can purportedly avoid the pain, numbness, and tingling associated with neuropathy.

To achieve those benefits, Golden After 50 has added alpha lipoic acid, turmeric, and other ingredients to their formula. These ingredients can purportedly help your body regenerate nerve endings, helping you avoid the pain associated with neuropathy. The minerals, vitamins, herbal extracts, and amino acids in Nerve Rejuv can purportedly soothe nerve pain in multiple ways. Golden After 50 specifically claims the formula can help with the pain associated with fibromyalgia, shingles, and other conditions, making it more than just another diabetic nerve pain supplement.

Price: $59



Nervexol is a nerve pain relief supplement designed to lessen and eliminate nerve pain. Launched in 2020, Nervexol contains ingredients like alpha lipoic acid, coenzyme Q10 (CoQ10), vitamin B1, and calamarine. Although other ingredients contain B vitamins to help with neuropathy, Nervexol is one of the only neuropathy supplements available with calamarine. Calamarine is a type of deep sea squid found off the coast of South America. It’s a rich source of omega-3 fatty acids that can support brain, joint, and eye health.

By adding calamarine and other unique ingredients to Nervexol, the company claims their formula can strengthen and nourish the nerves, give you a more comfortable sleep at night, and decrease the numbness, burning, stinging, and tingling sensation in your hands, feet, and legs.

Price: $69

Circle Labs CBD


Circle Labs offers CBD balms, tinctures, and creams that could soothe diabetic nerve pain. Many people take CBD daily to help with neuropathy. For some, it’s the only natural treatment that works. CBD works by interacting with your body’s endocannabinoid system, including your CB1 and CBD2 receptors. These receptors are found in cells throughout your body.

Circle Labs offers several CBD products, including its CBD Pain & Tension Balm, 3x Strength CBD Pain Stick, and CBD/CBDa tinctures and oils. By applying or taking these supplements daily, you can help your body restore nerve function. Some claim the Circle Labs CBD products relieve symptoms of neuropathy and nerve pain in a powerful way. If you want a unique option for neuropathy and haven’t found relief with other nerve pain supplements on this list, then Circle Labs’ CBD may be the right choice.

Price: $20 to $75

Nuturna Clinical Strength Neuropathy 900


Nuturna’s Clinical Strength Neuropathy 900 is the second Nuturna supplement on this list. Specifically designed to target neuropathy, Neuropathy 900 is one of the best-selling nerve pain supplements on Amazon and other major retailers. The supplement is frequently sold out.

Like other Nuturna supplements, Neuropathy 900 uses strong doses of all active ingredients. The supplement contains 900mg of alpha lipoic acid per serving along with hefty doses of L-arginine, acetyl-L-carnitine, organic turmeric root, and other plant and herbal extracts. Clinical trials typically use 300mg to 900mg of ALA per day, and Nuturna gives you a dose at the upper end of that spectrum. With Nuturna’s Clinical Strength Neuropathy 900, you get 18 total ingredients to target nerve pain and immune health.

Price: $49

Neuro Calm Pro


Neuro Calm Pro is the first supplement on this list that supports nerve health by targeting your ears. Designed as both a tinnitus supplement and nerve health supplement, Neuro Calm Pro uses natural ingredients to soothe irritated and damaged nerves, helping with neuropathy and nerve pain.

Developed by researcher Gerard Watson, Neuro Calm Pro uses ingredients like fenugreek extract, saw palmetto, L-tyrosine, and wild yam to soothe irritated nerves. Whether dealing with tinnitus, nerve pain, or general tingling and numbness in your extremities, Neuro Calm Pro may be able to help. The company also sells a similar supplement called Neuro Deep Calm advertised with similar benefits. As part of a recent promotion, all purchases also come with a digital sound therapy protocol, helping you use audio therapy to soothe irritated nerves.

Price: $69

Nervogen Pro


Nervogen Pro is a nutritional supplement that uses small doses of five active ingredients to target neuropathy. The supplement uses passion flower, marshmallow root, corydalis, prickly pear extract, and California poppy seed extract. According to the manufacturer, these ingredients can help with nerve pain, numbness, tingling, and more.

The reason Nervogen Pro is at the bottom of our list is because of dosage issues. With just 145mg of passion flower and less than 110mg each of other ingredients, Nervogen Pro lacks the dosage of its more powerful competitors. Despite the relatively low dosage, the manufacturer charges a premium price for Nervogen Pro. Although it could provide mild support for nerve pain and neuropathy, Nervogen Pro is unlikely to help serious cases of nerve pain.

Price: $69

Bonus Nerve Pain Guide #1: Neuropathy No More


Some people get relief from neuropathy supplements. Others use supplements as part of a range of treatment options. Blue Heron Health News has released an eBook called Neuropathy No More. Written by Jodi Knapp, the eBook is written under the assumption that neuropathy is a choice – not a life sentence. By implementing the protocols in this eBook, you can purportedly “choose to be free of neuropathy,” according to the author.

Neuropathy No More recommends adjusting your diet and lifestyle to target your neuropathy. Instead of taking drugs or using equipment to relieve neuropathy, you may get relief by simple lifestyle adjustments.

Neuropathy is a complex condition. In some people neuropathy can’t be cured. Neuropathy No More may not work for everyone. However, the guide is backed by a 60 day refund policy, allowing you to receive a complete refund if Jodi Knapp’s treatment plan does not work for you.

Price: $49

Bonus Nerve Pain Guide #2: Neuropathy Revolution


Neuropathy Revolution is a nerve pain guide that claims to melt your diabetic nerve pain away in 30 days. Like Neuropathy No More, Neuropathy Revolution is backed by a moneyback guarantee. You can obtain a complete refund if Neuropathy Revolution’s holistic strategies do not impact your neuropathy.

According to the authors of Neuropathy Revolution, you can use a seven-step holistic system to end chronic peripheral neuropathy and stop diabetic nerve pain “in as little as 24 hours.” The guide claims to help with all levels of nerve pain severity.

And, as part of a 2021 promotion, the authors of Neuropathy Revolution have bundled their program with an eBook called Diabetes Protocol. That eBook claims to “treat and fix the root cause of type 2 diabetes” using holistic strategies. After buying Neuropathy Revolution, you could get relief from neuropathy and diabetes, according to author Mark Fellers.

Price: $37

How We Ranked

Every neuropathy supplement claims to help with nerve pain. However, many supplements don’t work. Some contain unproven ingredients. Others contain the right ingredients – but at doses too low to affect the human body. To separate the best and worst nerve pain supplements, we used the following ranking factors:

Clinically Proven Ingredients: Peripheral neuropathy affects millions worldwide. Researchers have spent decades analyzing herbal extracts, plants, vitamins, minerals, and other nutrients to see how they impact neuropathy. We preferred neuropathy supplements that used the best, most clinically proven ingredients available.

Effective Doses: Some neuropathy supplements contain the right ingredients at the wrong doses. Some doses are too low. Other companies refuse to disclose dosage information, using proprietary formulas to hide low doses. We preferred supplements with doses similar to the doses used in clinical trials and scientific studies.

Price & Value: Good neuropathy supplements cost anywhere from $20 to $100. We featured neuropathy supplements at all different price ranges. However, we emphasized good value at every price. Whether you want to spend a few dollars or a few hundred dollars on a neuropathy treatment program, you can find a program for your budget.

Honest Advertised Benefits: Some diabetic nerve pain supplements claim to cure diabetes, eliminate neuropathy, and solve every health problem you have. Others are more honest about their benefits, claiming to support nerve health and help your body support blood sugar within a normal range, among other benefits. Legally, supplements cannot claim to cure illnesses or prevent diseases. Some supplement companies walk the line (or cross it), while others are more honest.

Transparent Labels: Transparent supplement labels are important. If you have a condition like diabetes, then you need to be careful with what you put into your body. Some supplement companies disclose their full list of ingredients and dosages upfront. Others only disclose some ingredients. Some hide dosages within proprietary labels, making it impossible to compare the formula to other supplements or scientific studies.

Manufacturer Reputation & Location: Some supplement companies disclose limited information about themselves, their manufacturing location, and their ingredient sources. Other neuropathy supplements are made by well-recognized names in the supplement space. We preferred reputable manufacturers over lesser-known providers.

Medical Advisory Board: The best supplement companies have a medical advisory board with medical doctors, naturopathic doctors, certified nutritionists, and other health and wellness professionals. Some supplement companies have invested in a medical advisory board. Others are backed by no medical advice whatsoever.

Proven Benefits: The best neuropathy supplements work. They relieve tingling, numbness, or pain in your extremities. Some work within days. Others work after a few weeks. Some don’t work at all. We tested formulas, analyzed customer reviews online, and used other metrics to determine each supplement’s effectiveness.

Scientific Evidence for Neuropathy Supplements

Most neuropathy supplements have not completed clinical trials. However, there’s plenty of research supporting individual ingredients within neuropathy supplements. We’ll summarize that research below and explain the best, most-proven neuropathy supplement ingredients.

Acetyl-L-carnitine is one of the most popular ingredients in neuropathy supplements. Your liver and kidneys naturally produce acetyl-L-carnitine. Some people take acetyl-L-carnitine supplements daily to support physical and cognitive energy. According to some small studies, acetyl-L-carnitine supplements could help with some symptoms of neuropathy. However, other studies have shown limited difference between acetyl-L-carnitine and a placebo. In this review, researchers found evidence that acetyl-L-carnitine could improve nerve function in people with diabetic neuropathy.

Most neuropathy supplements also contain B vitamins. Some contain vitamins B6 and B12. Others contain a specific mix of B complex vitamins. In this 2014 study, researchers found that vitamin B12 deficiency was linked to nerve dysfunction and other health issues. They also found that neuropathy due to vitamin B12 deficiency typically began in the feet. If you are deficient in vitamin B12 and have neuropathy, then it’s possible a vitamin B12 supplement could help.

In that same study, researchers analyzed the effects of vitamin B6 on neuropathy, concluding that vitamin B6 deficiency can lead to numbness or burning pain in the feet that scends to affect the legs and then the hands. Like vitamin B12 supplements, vitamin B6 supplements could help support nerve health if you are deficient in the vitamin.

Alpha lipoic acid (ALA) is an antioxidant-like chemical found in many neuropathy supplements sold online today. Some studies show that ALA could relieve the burning and stabbing pains associated with neuropathy – often within a few weeks. In this 2006 study, for example, researchers gave participants 600mg, 1,200mg, or 1,800mg of alpha lipoic acid per day, then tested the effects after five weeks. Researchers found patients reported fewer symptoms than a placebo at all three doses, although participants in the higher dosage range reported more side effects. Similarly, this study found that 300mg of alpha lipoic acid increased blood flow to the upper arm while also reducing inflammation, two effects that could help with neuropathy.

Some believe magnesium can help with neuropathy. According to the Foundation for Peripheral Neuropathy, magnesium has shown some evidence of helping with chemotherapy-related neuropathy, although they cautioned that more largescale research was needed to verify this connection. This study published in Nutrients found that patients undergoing chemotherapy had fewer symptoms of neuropathy when they had higher levels of magnesium, suggesting that magnesium impacts neuropathy in some way. However, a 2013 study did not find a connection between neuropathy and magnesium.

Glutamine is the most abundant amino acid in the human body. Studies show it could help with certain types of neuropathy by targeting inflammation, muscle pain, and numbness or tingling. You can get glutamine from a neuropathy supplement or glutamine supplement. You can also get it from wheat, peanuts, corn, soybeans, milk, egg whites, and other food sources. In this review study, researchers found that glutamine could eliminate or reduce the severity of neuropathy in patients with chemotherapy.

Glutathione is an antioxidant found in a growing number of neuropathy supplements. Early research has found glutathione could help with multiple types of neuropathy, including chemotherapy-related neuropathy, diabetic neuropathy, and other types of neuropathy linked to other conditions. The issue with glutathione is absorption: your body breaks down most glutathione before it’s absorbed, making it difficult to take glutathione in supplement form.

Researchers have found other ways to manage neuropathy, including diet and lifestyle factors. Studies show that controlling blood sugar, getting a shingles vaccine, engaging in physical activity, and reducing inflammation can help with neuropathy. If you smoke, quitting smoking could help with neuropathy because it improves blood flow. Anything that improves blood flow or reduces inflammation could help with neuropathy.

Ultimately, neuropathy can be a serious condition, and it’s important to talk to a doctor to manage the condition – especially if neuropathy symptoms are unbearable or getting worse. If you have severe neuropathy, you may not experience relief from supplements. You may need more serious treatments.

FAQs About Neuropathy Supplements

Q: What is neuropathy?

A: Neuropathy is a chronic condition caused by damage to or compression of the nerves outside the spinal cord and brain.

Q: What is peripheral neuropathy?

A: Peripheral neuropathy is another name for neuropathy. There is no difference between peripheral neuropathy and neuropathy.

Q: What’s the difference between mononeuropathy and polyneuropathy?

A: The condition is called mononeuropathy when it only affects one nerve, and it’s called polyneuropathy when it affects multiple nerves.

Q: What are the symptoms of neuropathy?

A: The most common neuropathy symptoms include numbness, pain, burning, tingling, and weakness in the hands and feet. Some experience neuropathy further up the arms and legs. If you’ve ever felt the ‘pins and needles’ sensation, then neuropathy can feel similar.

Q: What causes neuropathy?

A: Peripheral neuropathy occurs when your nerves are damaged or destroyed. Nerves send signals from your body to your brain. When these nerves are damaged or destroyed, it sends confusing signals to your brain, causing you to feel pain, numbness, or tingling.

Q: How do doctors treat neuropathy?

A: Doctors recommend different treatments for neuropathy based on your condition. Some doctors recommend pain medication and physical therapy. Others recommend topical medications or laser therapy. Many treatments target the symptoms of neuropathy without addressing the root cause, which is why many neuropathy supplements advertise themselves as long-term support supplements, addressing the underlying cause.

Q: How does neuropathy surgery work?

A: Neuropathy surgery is also known as nerve decompression. Performed in an outpatient setting, the surgery relieves compression points along the nerve. These pressure points could be causing your neuropathy symptoms.

Q: Why does neuropathy feel different in different people?

A: Neuropathy, like most nerve conditions, is complex. It affects different people in different ways. You may feel different neuropathy symptoms based on how your nerve signaling has been disrupted. The three main nerve signaling disruptions linked to neuropathy include:

Loss of signals normally sent (think of a broken wire)

Inappropriate signalling when there should not be any signalling (think of static on a telephone line)

Incorrect signalling that changes the messages being sent (like a distorted television picture)

Q: Does neuropathy hurt?

A: Neuropathy pain ranges from mild discomfort to extreme. The more serious your nerve damage is, the more pain you may feel.

Q: What nerves does neuropathy affect?

A: Neuropathy affects three main types of nerves, including:

Motor nerves, which control the conscious movement of muscles (like walking and talking)

Sensory nerves, which transmit information like touch, temperature, and pain throughout the body

Autonomic nerves, which control subconscious activities within your body (like breathing and digesting food)

Q: What are the most common causes of peripheral neuropathy?

A: We know neuropathy is caused by damaged nerves. However, people damage nerves in different ways. Some of the most common causes of neuropathy include:

Physical injury to the region, which is the most common cause of neuropathy. You might have an accident, a fall, or a sports injury, for example. Others experience neuropathy after a broken or dislocated bone.

Repetitive movements over time. Carpal tunnel syndrome is a type of neuropathy. Repetitive movements over time can damage nerves, especially when performing those movements incorrectly.

Diabetes. Diabetes causes more neuropathy in the United States than anything else. Approximately 70% of diabetics experience neuropathy at some level of severity. The longer you have diabetes, the more likely you are to develop neuropathy.

Vascular issues, blood problems, and circulatory disruptions. If your blood isn’t circulating properly to your peripheral nerves, then it starves those nerves of oxygen, leading to nerve tissue damage.

Smoking can cause or increase the chance of developing neuropathy. Smoking narrows blood vessels and is linked with high blood pressure.

Other issues, including autoimmune disorders and diseases, kidney and liver diseases, hormonal imbalances, certain types of cancer, chemotherapy drugs, and infections.

Q: How do doctors diagnose neuropathy?

A: It can be difficult to diagnose neuropathy. Patients experience different symptoms, and the severity of symptoms can vary even within a single patient. To diagnose neuropathy, doctors consider a patient’s medical history, conduct a physical and neurological exam, take body fluid tests, and perform genetic tests (if the cause of neuropathy is suspected to be genetic). Some doctors order nerve conduction velocity (NCV) tests to measure nerve signal strength. Other doctors request a nerve biopsy, electromyography (EMG) test, or neurodiagnostic skin biopsy.

Q: How do I prevent neuropathy?

A: The best way to avoid neuropathy is to take steps to prevent it today. Neuropathy is preventable in most people. Most neuropathy cases in the United States are caused by diabetes, and diabetes is preventable in most people. Simply losing weight can prevent neuropathy in many people. Talk to your doctor for neuropathy prevention strategies.

Q: Is neuropathy genetic?

A: Over 100 types of neuropathy have been identified, and some of these types are genetic. A type of neuropathy called Charcot-Marie-Tooth disease, for example, is considered a genetic nerve disorder. However, most neuropathy is caused by lifestyle factors – not genetics.

Q: Can prediabetes cause neuropathy?

A: Diabetics often develop neuropathy. However, it’s possible that pre-diabetics can develop neuropathy as well. If you have higher than normal blood sugar levels, then you could be pre-diabetic and at a higher risk of developing neuropathy.

Q: How do neuropathy supplements work?

A: Neuropathy supplements work in different ways. Some support blood flow and inflammation, helping your body deal with the root causes of neuropathy. Others flood your body with amino acids, herbal extracts, plant extracts, and other compounds linked to neuropathy relief.

Q: What’s the best neuropathy supplement?

A: Any of the top-ranked neuropathy supplements on our list can be considered the best neuropathy supplements available today.

Final Word

Neuropathy is a painful condition affecting millions of people. To help, some take nerve pain supplements or neuropathy supplements.

By taking the right neuropathy supplement, you could support nerve health throughout your body.

Again, any of these best nerve health supplements for neuropathy support should help users overcome the pain and discomfort:

Consider buying one of the top-ranked neuropathy supplements on our list to support your body’s defense against nerve pain.

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Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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